diff --git a/pkgs/development/python-modules/astropy-helpers/default.nix b/pkgs/development/python-modules/astropy-helpers/default.nix
index c803ac0449c3..f0938e83a7ab 100644
--- a/pkgs/development/python-modules/astropy-helpers/default.nix
+++ b/pkgs/development/python-modules/astropy-helpers/default.nix
@@ -1,30 +1,35 @@
 {
   lib,
   buildPythonPackage,
-  fetchPypi,
-  isPy3k,
-  pythonAtLeast,
+  fetchFromGitHub,
+  setuptools,
 }:
 
 buildPythonPackage rec {
   pname = "astropy-helpers";
   version = "4.0.1";
-  format = "setuptools";
+  pyproject = true;
 
-  # ModuleNotFoundError: No module named 'imp'
-  disabled = !isPy3k || pythonAtLeast "3.12";
-
-  doCheck = false; # tests requires sphinx-astropy
-
-  src = fetchPypi {
-    inherit pname version;
-    sha256 = "f1096414d108778218d6bea06d4d9c7b2ff7c83856a451331ac194e74de9f413";
+  src = fetchFromGitHub {
+    owner = "astropy";
+    repo = "astropy-helpers";
+    tag = "v${version}";
+    hash = "sha256-MjL/I+ApyoyoD2NmKuKWpDbyuEgvBb2OBhxqj/w/3lk=";
   };
 
-  meta = with lib; {
+  patches = [
+    # Fixes build with Python 3.12+
+    ./python-imp.patch
+  ];
+
+  build-system = [ setuptools ];
+
+  pythonImportsCheck = [ "astropy_helpers" ];
+
+  meta = {
     description = "Utilities for building and installing Astropy, Astropy affiliated packages, and their respective documentation";
     homepage = "https://github.com/astropy/astropy-helpers";
-    license = licenses.bsd3;
-    maintainers = [ maintainers.smaret ];
+    license = lib.licenses.bsd3;
+    maintainers = [ lib.maintainers.smaret ];
   };
 }
diff --git a/pkgs/development/python-modules/astropy-helpers/python-imp.patch b/pkgs/development/python-modules/astropy-helpers/python-imp.patch
new file mode 100644
index 000000000000..d12c2fb0e951
--- /dev/null
+++ b/pkgs/development/python-modules/astropy-helpers/python-imp.patch
@@ -0,0 +1,63 @@
+diff --git a/astropy_helpers/tests/test_git_helpers.py b/astropy_helpers/tests/test_git_helpers.py
+index 6b826fc..3fb3a29 100644
+--- a/astropy_helpers/tests/test_git_helpers.py
++++ b/astropy_helpers/tests/test_git_helpers.py
+@@ -1,5 +1,5 @@
+ import glob
+-import imp
++import importlib as imp
+ import os
+ import pkgutil
+ import re
+diff --git a/astropy_helpers/utils.py b/astropy_helpers/utils.py
+index 115c915..0cfc9e3 100644
+--- a/astropy_helpers/utils.py
++++ b/astropy_helpers/utils.py
+@@ -1,12 +1,12 @@
+ # Licensed under a 3-clause BSD style license - see LICENSE.rst
+ 
+ import contextlib
+-import imp
+ import os
+ import sys
+ import glob
+ 
+ from importlib import machinery as import_machinery
++from importlib import util as importlib_util
+ 
+ 
+ # Note: The following Warning subclasses are simply copies of the Warnings in
+@@ -54,9 +54,9 @@ def get_numpy_include_path():
+     import builtins
+     if hasattr(builtins, '__NUMPY_SETUP__'):
+         del builtins.__NUMPY_SETUP__
+-    import imp
++    import importlib
+     import numpy
+-    imp.reload(numpy)
++    importlib.reload(numpy)
+ 
+     try:
+         numpy_include = numpy.get_include()
+@@ -208,8 +208,6 @@ def import_file(filename, name=None):
+     # generates an underscore-separated name which is more likely to
+     # be unique, and it doesn't really matter because the name isn't
+     # used directly here anyway.
+-    mode = 'r'
+-
+     if name is None:
+         basename = os.path.splitext(filename)[0]
+         name = '_'.join(os.path.relpath(basename).split(os.sep)[1:])
+@@ -221,8 +219,10 @@ def import_file(filename, name=None):
+         loader = import_machinery.SourceFileLoader(name, filename)
+         mod = loader.load_module()
+     else:
+-        with open(filename, mode) as fd:
+-            mod = imp.load_module(name, fd, filename, ('.py', mode, 1))
++        importlib_util
++        spec = importlib_util.spec_from_file_location(name, filename)
++        mod = importlib_util.module_from_spec(spec)
++        spec.loader.exec_module(mod)
+ 
+     return mod
+ 
diff --git a/pkgs/development/python-modules/astroquery/default.nix b/pkgs/development/python-modules/astroquery/default.nix
index ff82ba44b9e3..7d7b6ee6240a 100644
--- a/pkgs/development/python-modules/astroquery/default.nix
+++ b/pkgs/development/python-modules/astroquery/default.nix
@@ -1,8 +1,10 @@
 {
-  pkgs,
+  lib,
   buildPythonPackage,
-  fetchPypi,
+  fetchFromGitHub,
+  fetchpatch2,
   astropy,
+  boto3,
   requests,
   keyring,
   beautifulsoup4,
@@ -17,22 +19,35 @@
   pyvo,
   astropy-helpers,
   setuptools,
-  isPy3k,
 }:
 
 buildPythonPackage rec {
   pname = "astroquery";
   version = "0.4.10";
-  format = "pyproject";
+  pyproject = true;
 
-  src = fetchPypi {
-    inherit pname version;
-    hash = "sha256-6s2R6do3jmQXQPvDEjhQ2qg7oJJqb/9MQMy/XcbVpAY=";
+  src = fetchFromGitHub {
+    owner = "astropy";
+    repo = "astroquery";
+    tag = "v${version}";
+    hash = "sha256-5pNKV+XNfUQca7WoWboVphXffzyVIHCmfxwr4nBMaEk=";
   };
 
-  disabled = !isPy3k;
+  patches = [
+    # https://github.com/astropy/astroquery/pull/3311
+    (fetchpatch2 {
+      name = "setuptools-package-index.patch";
+      url = "https://github.com/astropy/astroquery/commit/9d43beb4b7bea424d73fff0b602ca90026155519.patch";
+      hash = "sha256-3QdOwP1rlWeScGxHT9ZVPmffE7S1XE0cbtnQ8T4bIYw=";
+    })
+  ];
 
-  propagatedBuildInputs = [
+  build-system = [
+    astropy-helpers
+    setuptools
+  ];
+
+  dependencies = [
     astropy
     requests
     keyring
@@ -41,11 +56,6 @@ buildPythonPackage rec {
     pyvo
   ];
 
-  nativeBuildInputs = [
-    astropy-helpers
-    setuptools
-  ];
-
   # Disable automatic update of the astropy-helper module
   postPatch = ''
     substituteInPlace setup.cfg --replace "auto_use = True" "auto_use = False"
@@ -54,6 +64,7 @@ buildPythonPackage rec {
   nativeCheckInputs = [ pytestCheckHook ];
 
   checkInputs = [
+    boto3
     matplotlib
     pillow
     pytest
@@ -76,10 +87,10 @@ buildPythonPackage rec {
 
   pythonImportsCheck = [ "astroquery" ];
 
-  meta = with pkgs.lib; {
+  meta = {
     description = "Functions and classes to access online data resources";
     homepage = "https://astroquery.readthedocs.io/";
-    license = licenses.bsd3;
-    maintainers = [ maintainers.smaret ];
+    license = lib.licenses.bsd3;
+    maintainers = [ lib.maintainers.smaret ];
   };
 }