diff --git a/pkgs/development/python-modules/tpm2-pytss/default.nix b/pkgs/development/python-modules/tpm2-pytss/default.nix
index 6dcba1ef9535..fe5a361f9d8b 100644
--- a/pkgs/development/python-modules/tpm2-pytss/default.nix
+++ b/pkgs/development/python-modules/tpm2-pytss/default.nix
@@ -37,9 +37,6 @@ buildPythonPackage rec {
     [
       # Fix hardcoded `fapi-config.json` configuration path
       ./fapi-config.patch
-      # Backport for https://github.com/tpm2-software/tpm2-pytss/pull/576
-      # This is likely to be dropped with the next major release (>= 2.3)
-      ./pr576-backport.patch
     ]
     ++ lib.optionals isCross [
       # pytss will regenerate files from headers of tpm2-tss.
diff --git a/pkgs/development/python-modules/tpm2-pytss/pr576-backport.patch b/pkgs/development/python-modules/tpm2-pytss/pr576-backport.patch
deleted file mode 100644
index ee04701f3931..000000000000
--- a/pkgs/development/python-modules/tpm2-pytss/pr576-backport.patch
+++ /dev/null
@@ -1,117 +0,0 @@
-Backport for https://github.com/tpm2-software/tpm2-pytss/pull/576 on 2.2.1
-
-diff --git a/scripts/prepare_headers.py b/scripts/prepare_headers.py
-index 6ca9b64..a7529b3 100644
---- a/scripts/prepare_headers.py
-+++ b/scripts/prepare_headers.py
-@@ -32,6 +32,7 @@ def remove_common_guards(s):
- 
-     # Restructure #defines with ...
-     s = re.sub("(#define [A-Za-z0-9_]+) +\(\(.*?\) \(.*?\)\)", "\g<1>...", s)
-+    s = re.sub("(#define [A-Za-z0-9_]+) +\(\(\(.*?\) .*\)", "\g<1>...", s)
-     s = re.sub("(#define [A-Za-z0-9_]+) +\(\(.*?\).*?\) ", "\g<1>...", s)
-     s = re.sub(
-         "(#define [A-Za-z0-9_]+) .*\n.*?.*\)\)", "\g<1>...", s, flags=re.MULTILINE
-diff --git a/src/tpm2_pytss/internal/crypto.py b/src/tpm2_pytss/internal/crypto.py
-index 42030c5..f9d8c34 100644
---- a/src/tpm2_pytss/internal/crypto.py
-+++ b/src/tpm2_pytss/internal/crypto.py
-@@ -25,6 +25,7 @@ from cryptography.hazmat.backends import default_backend
- from cryptography.exceptions import UnsupportedAlgorithm, InvalidSignature
- from typing import Tuple, Type, Any
- import secrets
-+import inspect
- import sys
- 
- _curvetable = (
-diff --git a/test/test_encoding.py b/test/test_encoding.py
-index 1f58562..8cf4b51 100644
---- a/test/test_encoding.py
-+++ b/test/test_encoding.py
-@@ -1406,7 +1406,7 @@ class ToolsTest(TSS2_BaseTest):
-     def test_tools_decode_tpm2b_name(self):
-         if not self.has_tools:
-             self.skipTest("tools not in path")
--        key = ec.generate_private_key(ec.SECP256R1).public_key()
-+        key = ec.generate_private_key(ec.SECP256R1()).public_key()
-         kb = key.public_bytes(
-             serialization.Encoding.PEM, serialization.PublicFormat.SubjectPublicKeyInfo
-         )
-diff --git a/test/test_fapi.py b/test/test_fapi.py
-index f702fc9..6b77c66 100644
---- a/test/test_fapi.py
-+++ b/test/test_fapi.py
-@@ -13,7 +13,7 @@ from cryptography.hazmat.primitives.asymmetric.padding import PSS
- 
- from tpm2_pytss import *
- 
--from tpm2_pytss.internal.utils import is_bug_fixed, _lib_version_atleast
-+from tpm2_pytss.internal.utils import is_bug_fixed
- 
- from .TSS2_BaseTest import TpmSimulator
- from tpm2_pytss.TSS2_Exception import TSS2_Exception
-@@ -614,8 +614,7 @@ class Common:
-         self.fapi.sign(key_path, b"\x22" * 32)
- 
-     @pytest.mark.skipif(
--        _lib_version_atleast("tss2-fapi", "4.0.1-170")
--        or not is_bug_fixed(fixed_in="3.2", backports=["2.4.7", "3.0.5", "3.1.1"]),
-+        not is_bug_fixed(fixed_in="3.2", backports=["2.4.7", "3.0.5", "3.1.1"]),
-         reason="tpm2-tss bug, see #2084",
-     )
-     def test_write_authorize_nv(self, esys):
-@@ -662,8 +661,7 @@ class Common:
-             self.fapi.quote(path=key_path, pcrs=[7, 9])
- 
-     @pytest.mark.skipif(
--        _lib_version_atleast("tss2-fapi", "4.0.1-170")
--        or not is_bug_fixed(fixed_in="3.2", backports=["2.4.7", "3.0.5", "3.1.1"]),
-+        not is_bug_fixed(fixed_in="3.2", backports=["2.4.7", "3.0.5", "3.1.1"]),
-         reason="tpm2-tss bug, see #2084",
-     )
-     def test_authorize_policy(self, sign_key):
-@@ -728,9 +726,7 @@ class Common:
-             self.fapi.quote(path=key_path, pcrs=[7, 9])
- 
-     @pytest.mark.skipif(
--        _lib_version_atleast("tss2-fapi", "4.0.1-170")
--        or not is_bug_fixed(fixed_in="3.2"),
--        reason="tpm2-tss bug, see #2080",
-+        not is_bug_fixed(fixed_in="3.2"), reason="tpm2-tss bug, see #2080"
-     )
-     def test_policy_signed(self, cryptography_key):
-         # create external signing key used by the signing authority external to the TPM
-@@ -792,10 +788,6 @@ class Common:
-         with pytest.raises(TSS2_Exception):
-             self.fapi.sign(path=key_path, digest=b"\x11" * 32)
- 
--    @pytest.mark.skipif(
--        _lib_version_atleast("tss2-fapi", "4.0.1-170"),
--        reason="issue on master branch.",
--    )
-     def test_policy_branched(self):
-         pcr_index = 15
-         pcr_data = b"ABCDEF"
-@@ -913,8 +905,7 @@ class Common:
-         self.fapi.delete(path=nv_path)
- 
-     @pytest.mark.skipif(
--        _lib_version_atleast("tss2-fapi", "4.0.1-170")
--        or not is_bug_fixed(fixed_in="3.2", backports=["2.4.7", "3.0.5", "3.1.1"]),
-+        not is_bug_fixed(fixed_in="3.2", backports=["2.4.7", "3.0.5", "3.1.1"]),
-         reason="tpm2-tss bug, see #2089",
-     )
-     def test_policy_action(self):
-diff --git a/test/test_policy.py b/test/test_policy.py
-index f18aa8a..5f56e21 100644
---- a/test/test_policy.py
-+++ b/test/test_policy.py
-@@ -47,7 +47,7 @@ class TestPolicy(TSS2_EsapiTest):
-         super().setUp()
-         self._has_secp192r1 = True
-         try:
--            ec.generate_private_key(ec.SECP192R1)
-+            ec.generate_private_key(ec.SECP192R1())
-         except Exception:
-             self._has_secp192r1 = False
-