diff --git a/pkgs/development/interpreters/python/hooks/default.nix b/pkgs/development/interpreters/python/hooks/default.nix
index 46b01999f96c..e241bef042d5 100644
--- a/pkgs/development/interpreters/python/hooks/default.nix
+++ b/pkgs/development/interpreters/python/hooks/default.nix
@@ -1,7 +1,8 @@
 self: dontUse: with self;
 
 let
-  pythonInterpreter = python.pythonForBuild.interpreter;
+  inherit (python) pythonForBuild;
+  pythonInterpreter = pythonForBuild.interpreter;
   pythonSitePackages = python.sitePackages;
   pythonCheckInterpreter = python.interpreter;
   setuppy = ../run_setup.py;
@@ -81,6 +82,17 @@ in {
       };
     } ./pip-install-hook.sh) {};
 
+  pypaInstallHook = callPackage ({ makePythonHook, installer }:
+    makePythonHook {
+      name = "pypa-install-hook";
+      propagatedBuildInputs = [ installer ];
+      substitutions = {
+        inherit pythonInterpreter pythonSitePackages;
+      };
+    } ./pypa-install-hook.sh) {
+      inherit (pythonForBuild.pkgs) installer;
+    };
+
   pytestCheckHook = callPackage ({ makePythonHook, pytest }:
     makePythonHook {
       name = "pytest-check-hook";
diff --git a/pkgs/development/interpreters/python/hooks/pypa-install-hook.sh b/pkgs/development/interpreters/python/hooks/pypa-install-hook.sh
new file mode 100644
index 000000000000..1a7b30116904
--- /dev/null
+++ b/pkgs/development/interpreters/python/hooks/pypa-install-hook.sh
@@ -0,0 +1,21 @@
+# Setup hook for PyPA installer.
+echo "Sourcing pypa-install-hook"
+
+pypaInstallPhase() {
+    echo "Executing pypaInstallPhase"
+    runHook preInstall
+
+    for wheel in dist/*.whl; do
+        @pythonInterpreter@ -m installer --prefix "$out" "$wheel"
+    done
+
+    export PYTHONPATH="$out/@pythonSitePackages@:$PYTHONPATH"
+
+    runHook postInstall
+    echo "Finished executing pypaInstallPhase"
+}
+
+if [ -z "${dontUsePypaInstall-}" ] && [ -z "${installPhase-}" ]; then
+    echo "Using pypaInstallPhase"
+    installPhase=pypaInstallPhase
+fi