diff --git a/pkgs/by-name/gr/grenedalf/fix-genesis-cmake.patch b/pkgs/by-name/gr/grenedalf/fix-genesis-cmake.patch
new file mode 100644
index 000000000000..823229964223
--- /dev/null
+++ b/pkgs/by-name/gr/grenedalf/fix-genesis-cmake.patch
@@ -0,0 +1,16 @@
+diff --git a/libs/genesis/lib/genesis/CMakeLists.txt b/libs/genesis/lib/genesis/CMakeLists.txt
+index 8660c78..caa7618 100644
+--- a/libs/genesis/lib/genesis/CMakeLists.txt
++++ b/libs/genesis/lib/genesis/CMakeLists.txt
+@@ -66,11 +66,6 @@ if(${CMAKE_VERSION} VERSION_GREATER "3.9.0")
+     endif()
+ endif()
+ 
+-# Add htslib as a dependency, so that CMake realizes that it has to be built.
+-IF(GENESIS_USE_HTSLIB)
+-    add_dependencies( genesis_lib_obj htslib )
+-ENDIF()
+-
+ # Same for samtools. Not used at the moment though.
+ # IF(GENESIS_USE_SAMTOOLS)
+ #     add_dependencies( genesis_lib_obj samtools )
\ No newline at end of file
diff --git a/pkgs/by-name/gr/grenedalf/package.nix b/pkgs/by-name/gr/grenedalf/package.nix
index 914df31011c4..115c0f0d6dd6 100644
--- a/pkgs/by-name/gr/grenedalf/package.nix
+++ b/pkgs/by-name/gr/grenedalf/package.nix
@@ -26,20 +26,31 @@ let
       "--disable-libcurl"
       "--disable-plugins"
     ];
+    # Patches break the build
+    patches = [ ];
   });
 in
 stdenv.mkDerivation (finalAttrs: {
   pname = "grenedalf";
-  version = "0.6.2";
+  version = "0.6.3";
 
   src = fetchFromGitHub {
     owner = "lczech";
     repo = "grenedalf";
     tag = "v${finalAttrs.version}";
-    hash = "sha256-DJ7nZjOvYFQlN/L+S2QcMVvH/M9Dhla4VXl2nxc22m4=";
+    hash = "sha256-RD2WYhGBPJuBmbqrjDqujKj/djnxA5ED/LFmhHYIFyE=";
     fetchSubmodules = true;
   };
 
+  patches = [
+    ./fix-genesis-cmake.patch
+  ];
+
+  postPatch = ''
+    substituteInPlace CMakeLists.txt \
+      --replace-fail "cmake_minimum_required (VERSION 2.8.12 FATAL_ERROR)" "cmake_minimum_required (VERSION 3.5 FATAL_ERROR)"
+  '';
+
   nativeBuildInputs = [
     cmake
     pkg-config