diff --git a/pkgs/development/python-modules/python-mapnik/default.nix b/pkgs/development/python-modules/python-mapnik/default.nix
index 6e3717109ef3..044199f6c2a6 100644
--- a/pkgs/development/python-modules/python-mapnik/default.nix
+++ b/pkgs/development/python-modules/python-mapnik/default.nix
@@ -28,25 +28,21 @@
 
 buildPythonPackage rec {
   pname = "python-mapnik";
-  version = "unstable-2020-09-08";
+  version = "unstable-2023-02-23";
   format = "setuptools";
 
   src = fetchFromGitHub {
     owner = "mapnik";
     repo = "python-mapnik";
-    rev = "a2c2a86eec954b42d7f00093da03807d0834b1b4";
-    hash = "sha256-GwDdrutJOHtW7pIWiUAiu1xucmRvp7YFYB3YSCrDsrY=";
+    # Use proj6 branch in order to support Proj >= 6 (excluding commits after 2023-02-23)
+    # https://github.com/mapnik/python-mapnik/compare/master...proj6
+    rev = "687b2c72a24c59d701d62e4458c380f8c54f0549";
+    hash = "sha256-q3Snd3K/JndckwAVwSKU+kFK5E1uph78ty7mwVo/7Ik=";
     # Only needed for test data
     fetchSubmodules = true;
   };
 
   patches = [
-    # https://github.com/mapnik/python-mapnik/issues/239
-    (fetchpatch {
-      url = "https://github.com/koordinates/python-mapnik/commit/318b1edac16f48a7f21902c192c1dd86f6210a44.patch";
-      hash = "sha256-cfU8ZqPPGCqoHEyGvJ8Xy/bGpbN2vSDct6A3N5+I8xM=";
-    })
-    ./find-pycairo-with-pkg-config.patch
     # python-mapnik seems to depend on having the mapnik src directory
     # structure available at build time. We just hardcode the paths.
     (substituteAll {
@@ -107,36 +103,15 @@ buildPythonPackage rec {
 
   # https://github.com/mapnik/python-mapnik/issues/255
   disabledTests = [
-    "test_adding_datasource_to_layer"
-    "test_compare_map"
-    "test_dataraster_coloring"
-    "test_dataraster_query_point"
     "test_geometry_type"
-    "test_good_files"
-    "test_layer_init"
-    "test_load_save_map"
-    "test_loading_fontset_from_map"
+    "test_marker_ellipse_render1"
+    "test_marker_ellipse_render2"
     "test_normalizing_definition"
+    "test_passing_pycairo_context_pdf"
     "test_pdf_printing"
-    "test_proj_antimeridian_bbox"
-    "test_proj_transform_between_init_and_literal"
-    "test_pycairo_pdf_surface1"
-    "test_pycairo_svg_surface1"
-    "test_query_tolerance"
-    "test_raster_warping"
-    "test_raster_warping_does_not_overclip_source"
-    "test_render_points"
-    "test_render_with_scale_factor"
-    "test_style_level_comp_op"
-    "test_style_level_image_filter"
-    "test_that_coordinates_do_not_overflow_and_polygon_is_rendered_csv"
-    "test_that_coordinates_do_not_overflow_and_polygon_is_rendered_memory"
-    "test_transparency_levels"
-    "test_visual_zoom_all_rendering1"
     "test_visual_zoom_all_rendering2"
     "test_wgs84_inverse_forward"
   ] ++ lib.optionals stdenv.isDarwin [
-    "test_passing_pycairo_context_pdf"
     "test_passing_pycairo_context_svg"
   ];
 
diff --git a/pkgs/development/python-modules/python-mapnik/find-pycairo-with-pkg-config.patch b/pkgs/development/python-modules/python-mapnik/find-pycairo-with-pkg-config.patch
deleted file mode 100644
index 1f35af36ee82..000000000000
--- a/pkgs/development/python-modules/python-mapnik/find-pycairo-with-pkg-config.patch
+++ /dev/null
@@ -1,18 +0,0 @@
-diff --git a/setup.py b/setup.py
-index 82a31d733..1c876a553 100755
---- a/setup.py
-+++ b/setup.py
-@@ -228,10 +228,9 @@ extra_comp_args = list(filter(lambda arg: arg != "-fvisibility=hidden", extra_co
- if os.environ.get("PYCAIRO", "false") == "true":
-     try:
-         extra_comp_args.append('-DHAVE_PYCAIRO')
--        print("-I%s/include/pycairo".format(sys.exec_prefix))
--        extra_comp_args.append("-I{0}/include/pycairo".format(sys.exec_prefix))
--        #extra_comp_args.extend(check_output(["pkg-config", '--cflags', 'pycairo']).strip().split(' '))
--        #linkflags.extend(check_output(["pkg-config", '--libs', 'pycairo']).strip().split(' '))
-+        pycairo_name = 'py3cairo' if PYTHON3 else 'pycairo'
-+        extra_comp_args.extend(check_output(["pkg-config", '--cflags', pycairo_name]).strip().split(' '))
-+        linkflags.extend(check_output(["pkg-config", '--libs', pycairo_name]).strip().split(' '))
-     except:
-         raise Exception("Failed to find compiler options for pycairo")
-