diff --git a/pkgs/applications/editors/emacs/make-emacs.nix b/pkgs/applications/editors/emacs/make-emacs.nix
index b8156c5b3bcc..4f6fbd9a55c5 100644
--- a/pkgs/applications/editors/emacs/make-emacs.nix
+++ b/pkgs/applications/editors/emacs/make-emacs.nix
@@ -66,7 +66,11 @@
   zlib,
 
   # Boolean flags
-  withNativeCompilation ? stdenv.buildPlatform.canExecute stdenv.hostPlatform,
+
+  # FIXME: Native compilation breaks build and runtime on macOS 15.4;
+  # see <https://github.com/NixOS/nixpkgs/issues/395169>.
+  withNativeCompilation ?
+    stdenv.buildPlatform.canExecute stdenv.hostPlatform && !stdenv.hostPlatform.isDarwin,
   noGui ? false,
   srcRepo ? true,
   withAcl ? false,