diff --git a/pkgs/development/python-modules/ocrmypdf/default.nix b/pkgs/development/python-modules/ocrmypdf/default.nix
index 5c6b87b38fed..7f2bcf27db08 100644
--- a/pkgs/development/python-modules/ocrmypdf/default.nix
+++ b/pkgs/development/python-modules/ocrmypdf/default.nix
@@ -3,6 +3,7 @@
 , cffi
 , coloredlogs
 , fetchFromGitHub
+, fetchpatch
 , ghostscript
 , img2pdf
 , importlib-resources
@@ -55,6 +56,12 @@ buildPythonPackage rec {
       tesseract = "${lib.getBin tesseract4}/bin/tesseract";
       unpaper = "${lib.getBin unpaper}/bin/unpaper";
     })
+    # Fix support with pybind11 2.8.0
+    # https://github.com/jbarlow83/OCRmyPDF/issues/843
+    (fetchpatch {
+      url = "https://github.com/jbarlow83/OCRmyPDF/commit/690f88119d3ec24b17ddd14bb44832954a452e48.patch";
+      sha256 = "02z3jz85nmv1iilcp62hm5pyfgp6936ds67p1fhw49i8955q8pby";
+    })
   ];
 
   nativeBuildInputs = [