diff --git a/pkgs/tools/security/spyre/default.nix b/pkgs/tools/security/spyre/default.nix
index 6b86c910f9ae..3ec659373c7b 100644
--- a/pkgs/tools/security/spyre/default.nix
+++ b/pkgs/tools/security/spyre/default.nix
@@ -1,6 +1,7 @@
 { lib
 , buildGoModule
 , fetchFromGitHub
+, fetchpatch
 , pkg-config
 , yara
 }:
@@ -16,7 +17,22 @@ buildGoModule rec {
     hash = "sha256-wlGZTMCJE6Ki5/6R6J9EJP06/S125BNNd/jNPYGwKNw=";
   };
 
-  vendorHash = "sha256-qZkt5WwicDXrExwMT0tCO+FZgClIHhrVtMR8xNsdAaQ=";
+  patches = [
+    # The following two patches come from https://github.com/spyre-project/spyre/pull/75
+    # and improve Darwin support.
+    (fetchpatch {
+      name = "syscall-to-x-sys-unix.patch";
+      url = "https://github.com/spyre-project/spyre/commit/8f08daf030c847de453613eb2eb1befdb7300921.patch";
+      hash = "sha256-oy8Y85IubJVQrt0kmGA1hidZapgCw2aB6F/gT7uQ6KA=";
+    })
+    (fetchpatch {
+      name = "darwin-skip-dir.patch";
+      url = "https://github.com/spyre-project/spyre/commit/12dea550bc4f3275f8f406c19216ad140733a6af.patch";
+      hash = "sha256-BXLGOshyGnllbkvsbbmdnqvRHwycrjI52oGWBoXXgL0=";
+    })
+  ];
+
+  vendorHash = "sha256-aoeAnyFotKWWaRZQsgQPwwmhih/1zfL9eBV/2r1VPBM=";
 
   nativeBuildInputs = [
     pkg-config