diff --git a/pkgs/development/python-modules/pymisp/default.nix b/pkgs/development/python-modules/pymisp/default.nix
new file mode 100644
index 000000000000..076d8a210b2c
--- /dev/null
+++ b/pkgs/development/python-modules/pymisp/default.nix
@@ -0,0 +1,119 @@
+{
+  lib,
+  beautifulsoup4,
+  buildPythonPackage,
+  deprecated,
+  docutils,
+  extract-msg,
+  fetchFromGitHub,
+  lief,
+  myst-parser,
+  neo4j,
+  nix-update-script,
+  oletools,
+  poetry-core,
+  pure-magic-rs,
+  pydeep2,
+  pyfaup-rs,
+  pytestCheckHook,
+  python-dateutil,
+  reportlab,
+  requests,
+  rtfde,
+  sphinx-autodoc-typehints,
+  sphinx,
+  urllib3,
+  validators,
+}:
+
+buildPythonPackage (finalAttrs: {
+  pname = "pymisp";
+  version = "2.5.34.1";
+  pyproject = true;
+
+  __structuredAttrs = true;
+
+  src = fetchFromGitHub {
+    owner = "MISP";
+    repo = "PyMISP";
+    tag = "v${finalAttrs.version}";
+    hash = "sha256-68XJ6lqoNGnUneNIu0ZOKZhrumrt6CPLAt45UaZC5q0=";
+  };
+
+  build-system = [ poetry-core ];
+
+  dependencies = [
+    deprecated
+    python-dateutil
+    requests
+  ];
+
+  optional-dependencies = {
+    brotli = [ urllib3 ];
+    docs = [
+      docutils
+      myst-parser
+      sphinx
+      sphinx-autodoc-typehints
+    ];
+    email = [
+      extract-msg
+      oletools
+      rtfde
+    ];
+    fileobjects = [
+      lief
+      pure-magic-rs
+      pydeep2
+    ];
+    neo4j = [ neo4j ];
+    openioc = [ beautifulsoup4 ];
+    pdfexport = [ reportlab ];
+    url = [ pyfaup-rs ];
+    virustotal = [ validators ];
+  };
+
+  nativeCheckInputs = [
+    pytestCheckHook
+  ]
+  ++ lib.flatten (builtins.attrValues finalAttrs.passthru.optional-dependencies);
+
+  disabledTestPaths = [
+    # Test requires network access
+    "tests/test_reportlab.py"
+  ];
+
+  disabledTests = [
+    # AttributeError
+    "test_analyst_data_object_object_attribute_alternative"
+    "test_analyst_data_on_object"
+    "test_analyst_data_on_object_alternative"
+    "test_analyst_data_on_object_attribute"
+    "test_bom_encoded"
+    "test_default_attributes"
+    "test_feed"
+    "test_git_vuln_finder"
+    "test_handling_of_various_email_types"
+    "test_mail_1"
+    "test_mail_1_headers_only"
+    "test_mail_multiple_to"
+    "test_mimeType"
+    "test_msg"
+    "test_obj_default_values"
+    "test_object_galaxy"
+    "test_object_tag"
+    "test_to_dict_json_format"
+  ];
+
+  pythonImportsCheck = [ "pymisp" ];
+
+  passthru.updateScript = nix-update-script { };
+
+  meta = {
+    description = "Python library using the MISP Rest API";
+    homepage = "https://github.com/MISP/PyMISP";
+    changelog = "https://github.com/MISP/PyMISP/blob/${finalAttrs.src.rev}/CHANGELOG.txt";
+    license = lib.licenses.bsd2;
+    maintainers = with lib.maintainers; [ fab ];
+  };
+})
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index ba961d21e0ed..9c5a40510b08 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -14765,6 +14765,8 @@ self: super: with self; {
 
   pymilvus = callPackage ../development/python-modules/pymilvus { };
 
+  pymisp = callPackage ../development/python-modules/pymisp { };
+
   pymitsubishi = callPackage ../development/python-modules/pymitsubishi { };
 
   pymitv = callPackage ../development/python-modules/pymitv { };