diff --git a/pkgs/development/python-modules/qiskit-terra/default.nix b/pkgs/development/python-modules/qiskit-terra/default.nix
index b333497ed5db..98c328fae3d4 100644
--- a/pkgs/development/python-modules/qiskit-terra/default.nix
+++ b/pkgs/development/python-modules/qiskit-terra/default.nix
@@ -24,7 +24,6 @@
   stevedore,
   symengine,
   sympy,
-  tweedledum,
   withVisualization ? false,
   # Python visualization requirements, optional
   ipywidgets,
@@ -101,7 +100,6 @@ buildPythonPackage rec {
     stevedore
     symengine
     sympy
-    tweedledum
   ]
   ++ lib.optionals withVisualization visualizationPackages
   ++ lib.optionals withCrosstalkPass crosstalkPackages;
diff --git a/pkgs/development/python-modules/tweedledum/default.nix b/pkgs/development/python-modules/tweedledum/default.nix
deleted file mode 100644
index 365531bb7633..000000000000
--- a/pkgs/development/python-modules/tweedledum/default.nix
+++ /dev/null
@@ -1,47 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  fetchFromGitHub,
-  cmake,
-  ninja,
-  scikit-build,
-  # Check Inputs
-  pytestCheckHook,
-}:
-
-buildPythonPackage rec {
-  pname = "tweedledum";
-  version = "1.1.1";
-  format = "pyproject";
-
-  src = fetchFromGitHub {
-    owner = "boschmitt";
-    repo = "tweedledum";
-    rev = "v${version}";
-    hash = "sha256-wgrY5ajaMYxznyNvlD0ul1PFr3W8oV9I/OVsStlZEBM=";
-  };
-
-  postPatch = ''
-    sed -i '/\[project\]/a version = "${version}"' pyproject.toml
-    sed -i '/\[project\]/a name = "tweedledum"' pyproject.toml
-  '';
-
-  nativeBuildInputs = [
-    cmake
-    ninja
-    scikit-build
-  ];
-  dontUseCmakeConfigure = true;
-
-  pythonImportsCheck = [ "tweedledum" ];
-
-  nativeCheckInputs = [ pytestCheckHook ];
-  enabledTestPaths = [ "python/test" ];
-
-  meta = with lib; {
-    description = "Library for synthesizing and manipulating quantum circuits";
-    homepage = "https://github.com/boschmitt/tweedledum";
-    license = licenses.mit;
-    maintainers = [ ];
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index ada61035c432..a6973d6b0059 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -471,6 +471,7 @@ mapAliases {
   treex = throw "treex has been removed because it has transitively been marked as broken since 2023."; # Added 2025-10-11
   trezor_agent = throw "'trezor_agent' has been renamed to/replaced by 'trezor-agent'"; # Converted to throw 2025-10-29
   tvdb_api = throw "'tvdb_api' has been renamed to/replaced by 'tvdb-api'"; # Converted to throw 2025-10-29
+  tweedledum = throw "'tweedledum' has been removed due to lack of upstream maintenance."; # Added 2025-11-22
   typed-ast = throw "typed-ast was removed because it went end of life in July 2023"; # added 2025-05-24
   types-typed-ast = throw "types-typed-ast was removed because so was typed-ast"; # added 2025-05-24
   uamqp = throw "'uamqp' has been removed because it is broken and unmaintained."; # added 2025-06-11
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 2e47ec76190a..dbe562560264 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -19137,8 +19137,6 @@ self: super: with self; {
 
   tvdb-api = callPackage ../development/python-modules/tvdb-api { };
 
-  tweedledum = callPackage ../development/python-modules/tweedledum { };
-
   tweepy = callPackage ../development/python-modules/tweepy { };
 
   twentemilieu = callPackage ../development/python-modules/twentemilieu { };