diff --git a/pkgs/development/python-modules/gfal2-python/default.nix b/pkgs/development/python-modules/gfal2-python/default.nix
new file mode 100644
index 000000000000..d9ffbe8a23e7
--- /dev/null
+++ b/pkgs/development/python-modules/gfal2-python/default.nix
@@ -0,0 +1,53 @@
+{ lib
+, buildPythonPackage
+, fetchFromGitHub
+, cmake
+, pkg-config
+, boost
+, gfal2
+, glib
+, pythonAtLeast
+  # For tests
+, gfal2-util ? null
+}:
+buildPythonPackage rec {
+  pname = "gfal2-python";
+  version = "1.12.2";
+  src = fetchFromGitHub {
+    owner = "cern-fts";
+    repo = "gfal2-python";
+    rev = "v${version}";
+    hash = "sha256-Xk+gLTrqfWb0kGB6QhnM62zAHVFb8rRAqCIBxn0V824=";
+  };
+  nativeBuildInputs = [
+    cmake
+    pkg-config
+  ];
+  buildInputs = [
+    boost
+    gfal2
+    glib
+  ];
+  # We don't want setup.py to (re-)execute cmake in buildPhase
+  # Besides, this package is totally handled by CMake, which means no additional configuration is needed.
+  dontConfigure = true;
+  pythonImportsCheck = [
+    "gfal2"
+  ];
+  passthru = {
+    inherit gfal2;
+    tests = {
+      inherit gfal2-util;
+    }
+    // lib.optionalAttrs (gfal2-util != null) gfal2-util.tests or { };
+  };
+  meta = with lib; {
+    description = "Python binding for gfal2";
+    homepage = "https://github.com/cern-fts/gfal2-python";
+    license = licenses.asl20;
+    maintainers = with maintainers; [ ShamrockLee ];
+    # It currently fails to build against Python 3.12 or later,
+    # complaining CMake faililng to find Python include path, library path and site package path.
+    broken = pythonAtLeast "3.12";
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 496add388462..104a8f5ef2b5 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -4685,6 +4685,8 @@ self: super: with self; {
 
   gevent-websocket = callPackage ../development/python-modules/gevent-websocket { };
 
+  gfal2-python = callPackage ../development/python-modules/gfal2-python { };
+
   gflags = callPackage ../development/python-modules/gflags { };
 
   gflanguages = callPackage ../development/python-modules/gflanguages { };