diff --git a/pkgs/development/python-modules/trino-python-client/default.nix b/pkgs/development/python-modules/trino-python-client/default.nix
new file mode 100644
index 000000000000..479832bf9564
--- /dev/null
+++ b/pkgs/development/python-modules/trino-python-client/default.nix
@@ -0,0 +1,81 @@
+{ lib
+, buildPythonPackage
+, fetchFromGitHub
+  # build
+, setuptools
+  # required
+, pytz
+, requests
+, tzlocal
+  # optional
+, requests-kerberos
+, sqlalchemy
+, keyring
+  # tests
+, pytestCheckHook
+, httpretty
+}:
+
+buildPythonPackage rec {
+  pname = "trino-python-client";
+  version = "0.322.0";
+  format = "setuptools";
+
+  src = fetchFromGitHub {
+    repo = pname;
+    owner = "trinodb";
+    rev = "refs/tags/${version}";
+    hash = "sha256-Hl88Keavyp1QBw67AFbevy/btzNs7UlsKQ93K02YgLM=";
+  };
+
+  nativeBuildInputs = [
+    setuptools
+  ];
+
+  propagatedBuildInputs = [
+    pytz
+    requests
+    tzlocal
+  ];
+
+  passthru.optional-dependencies = lib.fix (self: {
+    kerberos = [
+      requests-kerberos
+    ];
+    sqlalchemy = [
+      sqlalchemy
+    ];
+    external-authentication-token-cache = [
+      keyring
+    ];
+    all = self.kerberos ++ self.sqlalchemy;
+  });
+
+  nativeCheckInputs = [
+    httpretty
+    pytestCheckHook
+  ] ++ passthru.optional-dependencies.all;
+
+  pythonImportsCheck = [
+    "trino"
+  ];
+
+  disabledTestPaths = [
+    # these all require a running trino instance
+    "tests/integration/test_types_integration.py"
+    "tests/integration/test_dbapi_integration.py"
+    "tests/integration/test_sqlalchemy_integration.py"
+  ];
+
+  pytestFlagsArray = [
+    "-k 'not auth'"
+  ];
+
+  meta = with lib; {
+    changelog = "https://github.com/trinodb/trino-python-client/blob/${version}/CHANGES.md";
+    description = "Client for the Trino distributed SQL Engine";
+    homepage = "https://github.com/trinodb/trino-python-client";
+    license = licenses.asl20;
+    maintainers = with maintainers; [ cpcloud ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index e79f1fb52e2a..7d91bd29cb39 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -12003,6 +12003,8 @@ self: super: with self; {
 
   trimesh = callPackage ../development/python-modules/trimesh { };
 
+  trino-python-client = callPackage ../development/python-modules/trino-python-client { };
+
   trio = callPackage ../development/python-modules/trio {
     inherit (pkgs) coreutils;
   };