diff --git a/pkgs/development/python-modules/sqlcipher3/default.nix b/pkgs/development/python-modules/sqlcipher3/default.nix
index 397b01d0e767..b4e4bfcd6787 100644
--- a/pkgs/development/python-modules/sqlcipher3/default.nix
+++ b/pkgs/development/python-modules/sqlcipher3/default.nix
@@ -19,6 +19,14 @@ buildPythonPackage {
     hash = "sha256-orZ1KJuoiJ84liWiHzoB8f8VmlUbW4j7qP2S2g4COAo=";
   };
 
+  postPatch = ''
+    # Remove conan from build dependencies; it is used upstream to fetch
+    # OpenSSL at build time, but we provide it via buildInputs instead.
+    # setup.py already handles the missing conan case gracefully.
+    substituteInPlace pyproject.toml \
+      --replace-fail '"conan>=2.0",' ""
+  '';
+
   build-system = [
     setuptools
   ];