diff --git a/pkgs/development/python-modules/pikepdf/default.nix b/pkgs/development/python-modules/pikepdf/default.nix
index c02e5c5ce0d5..bef67237a89c 100644
--- a/pkgs/development/python-modules/pikepdf/default.nix
+++ b/pkgs/development/python-modules/pikepdf/default.nix
@@ -25,7 +25,7 @@
 
 buildPythonPackage rec {
   pname = "pikepdf";
-  version = "4.4.1";
+  version = "5.0.1";
   disabled = ! isPy3k;
 
   src = fetchFromGitHub {
@@ -38,7 +38,7 @@ buildPythonPackage rec {
     extraPostFetch = ''
       rm "$out/.git_archival.txt"
     '';
-    hash = "sha256-8yYqyXz4ZqZxsk2Ka8S0rDsHaqO4l6cZTyNuVQuHkew=";
+    hash = "sha256-PlfVvCEutWaNQyhP4j44viAmjvBzUlZUvUbYQPcNL24=";
   };
 
   patches = [
diff --git a/pkgs/development/python-modules/pikepdf/paths.patch b/pkgs/development/python-modules/pikepdf/paths.patch
index 17349f7ac209..7db73bb1a6dd 100644
--- a/pkgs/development/python-modules/pikepdf/paths.patch
+++ b/pkgs/development/python-modules/pikepdf/paths.patch
@@ -1,5 +1,5 @@
 diff --git a/src/pikepdf/_methods.py b/src/pikepdf/_methods.py
-index 9db6b49..4020bcf 100644
+index 87e99fe..253a701 100644
 --- a/src/pikepdf/_methods.py
 +++ b/src/pikepdf/_methods.py
 @@ -204,7 +204,7 @@ def _mudraw(buffer, fmt) -> bytes:
@@ -12,15 +12,33 @@ index 9db6b49..4020bcf 100644
              check=True,
          )
 diff --git a/src/pikepdf/jbig2.py b/src/pikepdf/jbig2.py
-index 80cc910..64f6d31 100644
+index 04c762d..924727c 100644
 --- a/src/pikepdf/jbig2.py
 +++ b/src/pikepdf/jbig2.py
-@@ -25,7 +25,7 @@ def extract_jbig2(
-         global_path = Path(tmpdir) / "global"
+@@ -26,7 +26,7 @@ def extract_jbig2(
          output_path = Path(tmpdir) / "outfile"
  
--        args = ["jbig2dec", "-e", "-o", os.fspath(output_path)]
-+        args = ["@jbig2dec@", "-e", "-o", os.fspath(output_path)]
+         args = [
+-            "jbig2dec",
++            "@jbig2dec@",
+             "--embedded",
+             "--format",
+             "png",
+@@ -59,7 +59,7 @@ def extract_jbig2_bytes(jbig2: bytes, jbig2_globals: bytes) -> bytes:
+         output_path = Path(tmpdir) / "outfile"
  
-         # Get the raw stream, because we can't decode im_obj - that is why we are here
-         # (Strictly speaking we should remove any non-JBIG2 filters if double encoded)
+         args = [
+-            "jbig2dec",
++            "@jbig2dec@",
+             "--embedded",
+             "--format",
+             "png",
+@@ -84,7 +84,7 @@ def extract_jbig2_bytes(jbig2: bytes, jbig2_globals: bytes) -> bytes:
+ 
+ def jbig2dec_available() -> bool:
+     try:
+-        proc = run(['jbig2dec', '--version'], stdout=PIPE, check=True, encoding='ascii')
++        proc = run(['@jbig2dec@', '--version'], stdout=PIPE, check=True, encoding='ascii')
+     except (CalledProcessError, FileNotFoundError):
+         return False
+     else: