diff --git a/pkgs/development/python-modules/pillow-heif/default.nix b/pkgs/development/python-modules/pillow-heif/default.nix
index eea442596817..cc00832bb662 100644
--- a/pkgs/development/python-modules/pillow-heif/default.nix
+++ b/pkgs/development/python-modules/pillow-heif/default.nix
@@ -77,6 +77,17 @@ buildPythonPackage rec {
   disabledTests = [
     # Time sensitive speed test, not reproducible
     "test_decode_threads"
+    # Tests failing with libheif 1.22.0. To be removed in the next release
+    # https://github.com/bigcat88/pillow_heif/issues/424
+    # these check what happens when the ispe is not valid
+    "test_numpy_array_invalid_ispe"
+    "test_allow_incorrect_headers"
+    "test_invalid_ispe_ok"
+    "test_invalid_ispe_allow"
+    "test_invalid_ispe_stride"
+    "test_invalid_ispe_stride_pillow"
+    # disable version check for libheif
+    "test_libheif_info"
   ]
   ++ lib.optionals stdenv.hostPlatform.isDarwin [
     # https://github.com/bigcat88/pillow_heif/issues/89