diff --git a/pkgs/development/libraries/webkitgtk/default.nix b/pkgs/development/libraries/webkitgtk/default.nix
index 40cc38c2e852..80af6d45131d 100644
--- a/pkgs/development/libraries/webkitgtk/default.nix
+++ b/pkgs/development/libraries/webkitgtk/default.nix
@@ -86,7 +86,7 @@ in
 # https://webkitgtk.org/2024/10/04/webkitgtk-2.46.html recommends building with clang.
 clangStdenv.mkDerivation (finalAttrs: {
   pname = "webkitgtk";
-  version = "2.50.1";
+  version = "2.50.2";
   name = "webkitgtk-${finalAttrs.version}+abi=${abiVersion}";
 
   outputs = [
@@ -101,7 +101,7 @@ clangStdenv.mkDerivation (finalAttrs: {
 
   src = fetchurl {
     url = "https://webkitgtk.org/releases/webkitgtk-${finalAttrs.version}.tar.xz";
-    hash = "sha256-M+kS7m4820uYA3FfUGhq+Fpgr0fxz3KmrMai2xuz2f4=";
+    hash = "sha256-Gath8tROYs1ENnOUPS1TQbhNCEBfZ6fDe3p3rTVQ+IA=";
   };
 
   patches = lib.optionals clangStdenv.hostPlatform.isLinux [
@@ -118,6 +118,12 @@ clangStdenv.mkDerivation (finalAttrs: {
       hash = "sha256-MgaSpXq9l6KCLQdQyel6bQFHG53l3GY277WePpYXdjA=";
       name = "fix_ftbfs_riscv64.patch";
     })
+
+    # Remove the CustomToJSObject flag to avoid a link error due to an undefined toJS() symbol
+    (fetchpatch {
+      url = "https://github.com/WebKit/WebKit/commit/730bffd856d2a1e56dd3bd2a0702282f19c5242a.patch";
+      hash = "sha256-QRgYzr1Flk9BOV74/H7/38sRwc44BFFBhnX+xODgYX4=";
+    })
   ];
 
   nativeBuildInputs = [
@@ -265,11 +271,19 @@ clangStdenv.mkDerivation (finalAttrs: {
     mainProgram = "WebKitWebDriver";
     homepage = "https://webkitgtk.org/";
     license = licenses.bsd2;
-    pkgConfigModules = [
-      "javascriptcoregtk-${abiVersion}"
-      "webkit2gtk-${abiVersion}"
-      "webkit2gtk-web-extension-${abiVersion}"
-    ];
+    pkgConfigModules =
+      if lib.versionAtLeast abiVersion "6.0" then
+        [
+          "javascriptcoregtk-${abiVersion}"
+          "webkitgtk-${abiVersion}"
+          "webkitgtk-web-process-extension-${abiVersion}"
+        ]
+      else
+        [
+          "javascriptcoregtk-${abiVersion}"
+          "webkit2gtk-${abiVersion}"
+          "webkit2gtk-web-extension-${abiVersion}"
+        ];
     platforms = platforms.linux ++ platforms.darwin;
     teams = [ teams.gnome ];
     broken = clangStdenv.hostPlatform.isDarwin;