diff --git a/pkgs/development/python-modules/biocframe/default.nix b/pkgs/development/python-modules/biocframe/default.nix
new file mode 100644
index 000000000000..bb6f77f0d68c
--- /dev/null
+++ b/pkgs/development/python-modules/biocframe/default.nix
@@ -0,0 +1,52 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchFromGitHub,
+  pytestCheckHook,
+  pytest-cov-stub,
+  setuptools,
+  setuptools-scm,
+  biocutils,
+  numpy,
+  polars,
+  pandas,
+}:
+
+buildPythonPackage rec {
+  pname = "biocframe";
+  version = "0.6.3";
+  pyproject = true;
+
+  src = fetchFromGitHub {
+    owner = "BiocPy";
+    repo = "BiocFrame";
+    tag = "${version}";
+    hash = "sha256-HeXQEVDGrr/oEGqLcKgq2RLDA58sbYtc2O6oEdFxrIw=";
+  };
+
+  build-system = [
+    setuptools
+    setuptools-scm
+  ];
+
+  dependencies = [
+    biocutils
+    numpy
+  ];
+
+  nativeCheckInputs = [
+    pytest-cov-stub
+    pytestCheckHook
+    pandas
+    polars
+  ];
+
+  pythonImportsCheck = [ "biocframe" ];
+
+  meta = {
+    description = "Bioconductor-like data frames";
+    homepage = "https://github.com/BiocPy/BiocFrame";
+    license = lib.licenses.mit;
+    maintainers = with lib.maintainers; [ b-rodrigues ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index b24be35090c4..91bf65d44fd2 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -1915,6 +1915,8 @@ self: super: with self; {
 
   binsync = callPackage ../development/python-modules/binsync { };
 
+  biocframe = callPackage ../development/python-modules/biocframe { };
+
   biocutils = callPackage ../development/python-modules/biocutils { };
 
   biom-format = callPackage ../development/python-modules/biom-format { };