diff --git a/pkgs/development/libraries/python-qt/default.nix b/pkgs/development/libraries/python-qt/default.nix
deleted file mode 100644
index 7b70c94c1872..000000000000
--- a/pkgs/development/libraries/python-qt/default.nix
+++ /dev/null
@@ -1,66 +0,0 @@
-{
-  lib,
-  stdenv,
-  fetchFromGitHub,
-  python3,
-  qmake,
-  qtwebengine,
-  qtxmlpatterns,
-  qttools,
-}:
-
-stdenv.mkDerivation (finalAttrs: {
-  pname = "python-qt";
-  version = "3.6.1";
-
-  src = fetchFromGitHub {
-    owner = "MeVisLab";
-    repo = "pythonqt";
-    rev = "v${finalAttrs.version}";
-    hash = "sha256-OYFQtDGq+d32RQ0vChRKH//O9QgQPLMd1he8X3zCi+U=";
-  };
-
-  nativeBuildInputs = [
-    qmake
-    qttools
-    qtxmlpatterns
-    qtwebengine
-  ];
-
-  buildInputs = [ python3 ];
-
-  qmakeFlags = [
-    "PYTHON_DIR=${python3}"
-    "PYTHON_VERSION=3.${python3.sourceVersion.minor}"
-  ];
-
-  dontWrapQtApps = true;
-
-  installPhase = ''
-    mkdir -p $out/include/PythonQt
-    cp -r ./lib $out
-    cp -r ./src/* $out/include/PythonQt
-    cp -r ./build $out/include/PythonQt
-    cp -r ./extensions $out/include/PythonQt
-  '';
-
-  preFixup = lib.optionalString stdenv.hostPlatform.isDarwin ''
-    install_name_tool -id \
-      $out/lib/libPythonQt-Qt5-Python3.${python3.sourceVersion.minor}.dylib \
-      $out/lib/libPythonQt-Qt5-Python3.${python3.sourceVersion.minor}.dylib
-    install_name_tool -change \
-               libPythonQt-Qt5-Python3.${python3.sourceVersion.minor}.3.dylib \
-      $out/lib/libPythonQt-Qt5-Python3.${python3.sourceVersion.minor}.3.dylib \
-      -id \
-      $out/lib/libPythonQt_QtAll-Qt5-Python3.${python3.sourceVersion.minor}.dylib \
-      $out/lib/libPythonQt_QtAll-Qt5-Python3.${python3.sourceVersion.minor}.dylib
-  '';
-
-  meta = {
-    description = "PythonQt is a dynamic Python binding for the Qt framework. It offers an easy way to embed the Python scripting language into your C++ Qt applications";
-    homepage = "https://pythonqt.sourceforge.net/";
-    license = lib.licenses.lgpl21;
-    platforms = lib.platforms.all;
-    maintainers = with lib.maintainers; [ hlolli ];
-  };
-})
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index f74111e1ecec..6bd244744d77 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -1418,6 +1418,7 @@ mapAliases {
   python313Full = throw "python313Full has been removed. Bluetooth support is now enabled by default. The tkinter package is available within the package set."; # Added 2025-08-30
   python314Full = throw "python314Full has been removed. Bluetooth support is now enabled by default. The tkinter package is available within the package set."; # Added 2025-08-30
   python = throw "`python` previously pointed to Python 2; use `python3` or `python2` if necessary"; # Converted to throw 2025-10-27
+  python-qt = throw "python-qt has been removed, because hard to maintain and not required by anything"; # Added 2025-01-14
   pythonFull = throw "'pythonFull' previously pointed to Python 2; use `python3` or `python2Full` if necessary"; # Converted to throw 2025-10-27
   pythonPackages = throw "`pythonPackages` previously pointed to Python 2; use `python3Packages` or `python2.pkgs` if necessary"; # Converted to throw 2025-10-27
   q2pro = throw "'q2pro' has been removed as upstream repository was deleted and no direct active forks were available."; # Added 2025-12-27
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 746d96f57baf..1ebd65a57340 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -8005,8 +8005,6 @@ with pkgs;
 
   pth = if stdenv.hostPlatform.isMusl then npth else gnupth;
 
-  python-qt = libsForQt5.callPackage ../development/libraries/python-qt { };
-
   pyotherside = libsForQt5.callPackage ../development/libraries/pyotherside { };
 
   qbs = libsForQt5.callPackage ../development/tools/build-managers/qbs { };
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index 55eb3d572c60..f633a7ecc96b 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -392,6 +392,7 @@ mapAliases {
   python-jsonrpc-server = throw "python-jsonrpc-server has been removed because it was no longer used by anything"; # added 2025-11-11
   python-Levenshtein = throw "'python-Levenshtein' has been renamed to/replaced by 'levenshtein'"; # Converted to throw 2025-10-29
   python-lz4 = throw "'python-lz4' has been renamed to/replaced by 'lz4'"; # Converted to throw 2025-10-29
+  python-qt = throw "python-qt has been removed, because hard to maintain and not required by anything"; # Added 2025-01-14
   python-simple-hipchat = throw "'python-simple-hipchat' has been removed because it was broken and unmaintained"; # added 2025-08-26
   python-subunit = throw "'python-subunit' has been renamed to/replaced by 'subunit'"; # Converted to throw 2025-10-29
   python-u2flib-server = throw "'python-u2flib-server' has been removed, since it was broken and archived upstream"; # added 2025-11-08
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 56376101a6cb..421778284a04 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -15527,8 +15527,6 @@ self: super: with self; {
 
   python-ptrace = callPackage ../development/python-modules/python-ptrace { };
 
-  python-qt = toPythonModule (pkgs.python-qt.override { python3 = self.python; });
-
   python-rabbitair = callPackage ../development/python-modules/python-rabbitair { };
 
   python-rapidjson = callPackage ../development/python-modules/python-rapidjson { };