diff --git a/pkgs/development/python-modules/clr-loader/default.nix b/pkgs/development/python-modules/clr-loader/default.nix
index 87316f6deeaa..9b34590b5909 100644
--- a/pkgs/development/python-modules/clr-loader/default.nix
+++ b/pkgs/development/python-modules/clr-loader/default.nix
@@ -19,31 +19,42 @@ let
     inherit version;
     hash = "sha256-AZNIrmtqg8ekBtFFN8J3zs96OlOyY+w0LIHe1YRaZ+4=";
   };
+  patches = [ ./dotnet-8-upgrade.patch ];
 
   # This buildDotnetModule is used only to get nuget sources, the actual
   # build is done in `buildPythonPackage` below.
   dotnet-build = buildDotnetModule {
-    inherit pname version src;
+    inherit
+      pname
+      version
+      src
+      patches
+      ;
     projectFile = [
       "netfx_loader/ClrLoader.csproj"
       "example/example.csproj"
     ];
     nugetDeps = ./deps.json;
-    dotnet-sdk = dotnetCorePackages.sdk_6_0;
+    dotnet-sdk = dotnetCorePackages.sdk_8_0;
   };
 in
 buildPythonPackage {
-  inherit pname version src;
+  inherit
+    pname
+    version
+    src
+    patches
+    ;
 
   format = "pyproject";
 
-  buildInputs = dotnetCorePackages.sdk_6_0.packages ++ dotnet-build.nugetDeps;
+  buildInputs = dotnetCorePackages.sdk_8_0.packages ++ dotnet-build.nugetDeps;
 
   nativeBuildInputs = [
     setuptools
     setuptools-scm
     wheel
-    dotnetCorePackages.sdk_6_0
+    dotnetCorePackages.sdk_8_0
   ];
 
   propagatedBuildInputs = [ cffi ];
diff --git a/pkgs/development/python-modules/clr-loader/deps.json b/pkgs/development/python-modules/clr-loader/deps.json
index ba094f13d934..f787d633257a 100644
--- a/pkgs/development/python-modules/clr-loader/deps.json
+++ b/pkgs/development/python-modules/clr-loader/deps.json
@@ -2,31 +2,31 @@
   {
     "pname": "Microsoft.NETCore.Platforms",
     "version": "1.1.0",
-    "sha256": "08vh1r12g6ykjygq5d3vq09zylgb84l63k49jc4v8faw9g93iqqm"
+    "hash": "sha256-FeM40ktcObQJk4nMYShB61H/E8B7tIKfl9ObJ0IOcCM="
   },
   {
     "pname": "Microsoft.NETFramework.ReferenceAssemblies",
     "version": "1.0.0",
-    "sha256": "0na724xhvqm63vq9y18fl9jw9q2v99bdwr353378s5fsi11qzxp9"
+    "hash": "sha256-6faPQ4jaFY3OGGVk3lZKW+DEZaIOBZ/wHqbiDTsRR1k="
   },
   {
     "pname": "Microsoft.NETFramework.ReferenceAssemblies.net461",
     "version": "1.0.0",
-    "sha256": "00vkn4c6i0rn1l9pv912y0wgb9h6ks76qah8hvk441nari8fqbm1"
+    "hash": "sha256-oS7sUMzKBkLmhggqbI6eBqb1OPAipH0TDTaDaBixcwM="
   },
   {
     "pname": "Microsoft.NETFramework.ReferenceAssemblies.net47",
     "version": "1.0.0",
-    "sha256": "00v56phfn01ahf4fq7zanz6hjyzpp00hkkk4a190l0dywrv387i6"
+    "hash": "sha256-Jh40dua+AQpSUGTOCQG493sJzbfqH+yIgyoA6+A1ZQM="
   },
   {
     "pname": "NETStandard.Library",
     "version": "2.0.3",
-    "sha256": "1fn9fxppfcg4jgypp2pmrpr6awl3qz1xmnri0cygpkwvyx27df1y"
+    "hash": "sha256-Prh2RPebz/s8AzHb2sPHg3Jl8s31inv9k+Qxd293ybo="
   },
   {
     "pname": "NXPorts",
     "version": "1.0.0",
-    "sha256": "02zva596c3vsnlhi1b1391vbfl8a6142dvm61r8j1c70b07916lj"
+    "hash": "sha256-kpqQDljgsCBRDqbuJkgwClG3dkgjrBAhtXoPZlJR+ws="
   }
 ]
diff --git a/pkgs/development/python-modules/clr-loader/dotnet-8-upgrade.patch b/pkgs/development/python-modules/clr-loader/dotnet-8-upgrade.patch
new file mode 100644
index 000000000000..d261dfc9e3cc
--- /dev/null
+++ b/pkgs/development/python-modules/clr-loader/dotnet-8-upgrade.patch
@@ -0,0 +1,31 @@
+diff --git a/example/example.csproj b/example/example.csproj
+index fd6d566..ed76d15 100644
+--- a/example/example.csproj
++++ b/example/example.csproj
+@@ -1,6 +1,6 @@
+ <Project Sdk="Microsoft.NET.Sdk">
+   <PropertyGroup>
+-    <TargetFrameworks>net60;netstandard20</TargetFrameworks>
++    <TargetFrameworks>net8.0;netstandard2.0</TargetFrameworks>
+     <GenerateRuntimeConfigurationFiles>true</GenerateRuntimeConfigurationFiles>
+   </PropertyGroup>
+   <ItemGroup>
+diff --git a/tests/test_common.py b/tests/test_common.py
+index 8a9e36d..8370024 100644
+--- a/tests/test_common.py
++++ b/tests/test_common.py
+@@ -8,12 +8,12 @@ from pathlib import Path
+ 
+ @pytest.fixture(scope="session")
+ def example_netstandard(tmpdir_factory):
+-    return build_example(tmpdir_factory, "netstandard20")
++    return build_example(tmpdir_factory, "netstandard2.0")
+ 
+ 
+ @pytest.fixture(scope="session")
+ def example_netcore(tmpdir_factory):
+-    return build_example(tmpdir_factory, "net60")
++    return build_example(tmpdir_factory, "net8.0")
+ 
+ 
+ def build_example(tmpdir_factory, framework):