diff --git a/pkgs/by-name/gn/gnome-settings-daemon46/add-gnome-session-ctl-option.patch b/pkgs/by-name/gn/gnome-settings-daemon46/add-gnome-session-ctl-option.patch
new file mode 100644
index 000000000000..8bdf39ce37b6
--- /dev/null
+++ b/pkgs/by-name/gn/gnome-settings-daemon46/add-gnome-session-ctl-option.patch
@@ -0,0 +1,58 @@
+From aae1e774dd9de22fe3520cf9eb2bfbf7216f5eb0 Mon Sep 17 00:00:00 2001
+From: WORLDofPEACE <worldofpeace@protonmail.ch>
+Date: Sun, 20 Sep 2020 16:09:36 -0400
+Subject: [PATCH] build: add a gnome_session_ctl_path option
+
+In gsd.service.in the ExecStopPost expects g-s-d libexecdir to
+be from the same prefix as gnome-session's, and this is not necessarily
+true as there are linux distro's that install their packages into their
+own individual prefixes (like NixOS or Guix).
+---
+ meson_options.txt      | 1 +
+ plugins/gsd.service.in | 2 +-
+ plugins/meson.build    | 6 ++++++
+ 3 files changed, 8 insertions(+), 1 deletion(-)
+
+diff --git a/meson_options.txt b/meson_options.txt
+index 3e04cf64f..21e003c61 100644
+--- a/meson_options.txt
++++ b/meson_options.txt
+@@ -1,4 +1,5 @@
+ option('udev_dir', type: 'string', value: '', description: 'Absolute path of the udev base directory')
++option('gnome_session_ctl_path', type: 'string', value: '', description: 'Absolute path to the gnome-session-ctl binary')
+ option('systemd', type: 'boolean', value: true, description: 'Enable systemd integration')
+ 
+ option('alsa', type: 'boolean', value: true, description: 'build with ALSA support (not optional on Linux platforms)')
+diff --git a/plugins/gsd.service.in b/plugins/gsd.service.in
+index 79b5f5536..bfbde6d05 100644
+--- a/plugins/gsd.service.in
++++ b/plugins/gsd.service.in
+@@ -23,4 +23,4 @@ BusName=@plugin_dbus_name@
+ TimeoutStopSec=5
+ # We cannot use OnFailure as e.g. dependency failures are normal
+ # https://github.com/systemd/systemd/issues/12352
+-ExecStopPost=@libexecdir@/gnome-session-ctl --exec-stop-check
++ExecStopPost=@gnome_session_ctl@ --exec-stop-check
+diff --git a/plugins/meson.build b/plugins/meson.build
+index 83e018854..266a0f093 100644
+--- a/plugins/meson.build
++++ b/plugins/meson.build
+@@ -20,6 +20,11 @@ all_plugins = [
+ 
+ disabled_plugins = []
+ 
++gnome_session_ctl = get_option('gnome_session_ctl_path')
++if gnome_session_ctl == ''
++  gnome_session_ctl = join_paths(gsd_libexecdir, 'gnome-session-ctl')
++endif
++
+ if not enable_smartcard
+     disabled_plugins += ['smartcard']
+ endif
+@@ -125,6 +130,7 @@ foreach plugin: all_plugins
+         unit_conf.set('plugin_name', plugin_name)
+         unit_conf.set('description', plugin_description)
+         unit_conf.set('libexecdir', gsd_libexecdir)
++        unit_conf.set('gnome_session_ctl', gnome_session_ctl)
+         unit_conf.set('plugin_dbus_name', plugin_dbus_name)
+         unit_conf.set('plugin_restart', plugin_restart_rule.get(plugin_name, 'on-failure'))
diff --git a/pkgs/by-name/gn/gnome-settings-daemon43/fix-paths.patch b/pkgs/by-name/gn/gnome-settings-daemon46/fix-paths.patch
similarity index 100%
rename from pkgs/by-name/gn/gnome-settings-daemon43/fix-paths.patch
rename to pkgs/by-name/gn/gnome-settings-daemon46/fix-paths.patch
diff --git a/pkgs/by-name/gn/gnome-settings-daemon43/package.nix b/pkgs/by-name/gn/gnome-settings-daemon46/package.nix
similarity index 86%
rename from pkgs/by-name/gn/gnome-settings-daemon43/package.nix
rename to pkgs/by-name/gn/gnome-settings-daemon46/package.nix
index 23d0a8eaa720..d7b00a0a2ef9 100644
--- a/pkgs/by-name/gn/gnome-settings-daemon43/package.nix
+++ b/pkgs/by-name/gn/gnome-settings-daemon46/package.nix
@@ -1,7 +1,6 @@
 {
   stdenv,
   lib,
-  fetchpatch,
   substituteAll,
   fetchurl,
   meson,
@@ -13,7 +12,6 @@
   glib,
   libnotify,
   libgnomekbd,
-  lcms2,
   libpulseaudio,
   alsa-lib,
   libcanberra-gtk3,
@@ -36,26 +34,22 @@
   wrapGAppsHook3,
   python3,
   tzdata,
-  nss,
   gcr_4,
   gnome-session-ctl,
 }:
 
 stdenv.mkDerivation (finalAttrs: {
   pname = "gnome-settings-daemon";
-  version = "43.0";
+  version = "46.0";
 
   src = fetchurl {
     url = "mirror://gnome/sources/gnome-settings-daemon/${lib.versions.major finalAttrs.version}/gnome-settings-daemon-${finalAttrs.version}.tar.xz";
-    hash = "sha256-NRO7JPxvgYFmciOmSgZ1NP3M879mMmqUA9OLDw1gE9A=";
+    hash = "sha256-C5oPZPoYqOfgm0yVo/dU+gM8LNvS3DVwHwYYVywcs9c=";
   };
 
   patches = [
     # https://gitlab.gnome.org/GNOME/gnome-settings-daemon/-/merge_requests/202
-    (fetchpatch {
-      url = "https://gitlab.gnome.org/GNOME/gnome-settings-daemon/commit/aae1e774dd9de22fe3520cf9eb2bfbf7216f5eb0.patch";
-      hash = "sha256-O4m0rOW8Zrgu3Q0p0OA8b951VC0FjYbOUk9MLzB9icI=";
-    })
+    ./add-gnome-session-ctl-option.patch
 
     (substituteAll {
       src = ./fix-paths.patch;
@@ -85,14 +79,12 @@ stdenv.mkDerivation (finalAttrs: {
     libnotify
     libgnomekbd # for org.gnome.libgnomekbd.keyboard schema
     gnome-desktop
-    lcms2
     libpulseaudio
     alsa-lib
     libcanberra-gtk3
     upower
     colord
     libgweather
-    nss
     polkit
     geocode-glib_2
     geoclue2
diff --git a/pkgs/desktops/gnome/default.nix b/pkgs/desktops/gnome/default.nix
index 04bac8d94227..43c83c2076c7 100644
--- a/pkgs/desktops/gnome/default.nix
+++ b/pkgs/desktops/gnome/default.nix
@@ -91,7 +91,7 @@ in
   gnome-session = throw "The ‘gnome.gnome-session’ was moved to top-level. Please use ‘pkgs.gnome-session’ directly."; # Added on 2024-08-28.
   gnome-session-ctl = throw "The ‘gnome.gnome-session-ctl’ was moved to top-level. Please use ‘pkgs.gnome-session-ctl’ directly."; # Added on 2024-08-28.
   gnome-settings-daemon = throw "The ‘gnome.gnome-settings-daemon’ was moved to top-level. Please use ‘pkgs.gnome-settings-daemon’ directly."; # Added on 2024-08-28.
-  gnome-settings-daemon43 = throw "The ‘gnome.gnome-settings-daemon43’ was moved to top-level. Please use ‘pkgs.gnome-settings-daemon43’ directly."; # Added on 2024-08-28.
+  gnome-settings-daemon43 = throw "The ‘gnome.gnome-settings-daemon43’ was removed since it is no longer used by Pantheon."; # Added on 2024-08-28.
   gnome-shell = throw "The ‘gnome.gnome-shell’ was moved to top-level. Please use ‘pkgs.gnome-shell’ directly."; # Added on 2024-08-28.
   gnome-shell-extensions = throw "The ‘gnome.gnome-shell-extensions’ was moved to top-level. Please use ‘pkgs.gnome-shell-extensions’ directly."; # Added on 2024-08-11.
   gnome-software = throw "The ‘gnome.gnome-software’ was moved to top-level. Please use ‘pkgs.gnome-software’ directly."; # Added on 2024-08-11.
diff --git a/pkgs/desktops/pantheon/default.nix b/pkgs/desktops/pantheon/default.nix
index 4a55e1e09193..86ae59b2fb80 100644
--- a/pkgs/desktops/pantheon/default.nix
+++ b/pkgs/desktops/pantheon/default.nix
@@ -41,7 +41,7 @@ lib.makeScope pkgs.newScope (self: with self; {
   mutter = pkgs.mutter46;
 
   # Using 43 to match Mutter used in Pantheon
-  gnome-settings-daemon = pkgs.gnome-settings-daemon43;
+  gnome-settings-daemon = pkgs.gnome-settings-daemon46;
 
   elementary-gsettings-schemas = callPackage ./desktop/elementary-gsettings-schemas { };
 
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index c8816a70d739..f82ecfe363d1 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -456,6 +456,7 @@ mapAliases {
   gmtk = throw "'gmtk' has been removed due to lack of maintenance upstream"; # Added 2024-09-14
   gmtp = throw "'gmtp' has been removed due to lack of maintenance upstream. Consider using 'gnome-music' instead"; # Added 2024-09-14
   gnome-latex = throw "'gnome-latex' has been superseded by 'enter-tex'"; # Added 2024-09-18
+  gnome-settings-daemon43 = throw "'gnome-settings-daemon43' has been removed since it is no longer used by Pantheon."; # Added 2024-09-22
   gnu-cobol = gnucobol; # Added 2024-09-17
   gnupg22 = throw "'gnupg22' is end-of-life. Consider using 'gnupg24' instead"; # Added 2025-01-05
   gogs = throw ''