diff --git a/pkgs/development/python-modules/libmobility/default.nix b/pkgs/development/python-modules/libmobility/default.nix
new file mode 100644
index 000000000000..bb4b74e1ffe7
--- /dev/null
+++ b/pkgs/development/python-modules/libmobility/default.nix
@@ -0,0 +1,170 @@
+{
+  lib,
+  config,
+  buildPythonPackage,
+  fetchFromGitHub,
+  python,
+
+  # build-system
+  cmake,
+  nanobind,
+  setuptools,
+
+  # nativeBuildInputs
+  autoAddDriverRunpath,
+  cudaPackages,
+
+  # buildInputs
+  blas,
+  lapack,
+
+  # dependencies
+  numpy,
+  scipy,
+
+  # tests
+  pytest-xdist,
+  pytestCheckHook,
+
+  # passthru
+  libmobility,
+}:
+let
+  uammd-src = fetchFromGitHub {
+    owner = "RaulPPelaez";
+    repo = "uammd";
+    tag = "v3.0.1";
+    hash = "sha256-/7ceXlA96dZQs1WzkV1OpRv61xa0Tdt5gFe17I0s1BI=";
+  };
+in
+buildPythonPackage.override { stdenv = cudaPackages.backendStdenv; } (finalAttrs: {
+  pname = "libmobility";
+  version = "1.1.2";
+  pyproject = true;
+  __structuredAttrs = true;
+
+  src = fetchFromGitHub {
+    owner = "stochasticHydroTools";
+    repo = "libMobility";
+    tag = "v${finalAttrs.version}";
+    hash = "sha256-7jUpVR4bS9vkgeKN68of6VNZzGPlQMcRMBStQ+wFEx4=";
+  };
+
+  postPatch =
+    # Various setup.py patches:
+    # - Inject nix's cmakeFlags
+    # - Patch install destination
+    # - Don't let setuptools ship the `solvers/` directory as the package is
+    #   already installed by cmake
+    # - Patch the version
+    ''
+      substituteInPlace setup.py \
+        --replace-fail \
+          "cmake_args = [" \
+          "cmake_args = [${lib.concatStringsSep "," (map (f: "'${f}'") finalAttrs.cmakeFlags)}," \
+        --replace-fail \
+          "sys.prefix" \
+          'os.environ["out"]' \
+        --replace-fail \
+          "packages=find_packages()," \
+          "packages=[]," \
+        --replace-fail \
+          'version = "0"' \
+          'version = "${finalAttrs.version}"'
+    ''
+    # Upstream installs the modules into the (read-only) absolute `Python_SITEARCH`.
+    # Make the destination relative so it lands under CMAKE_INSTALL_PREFIX ($out).
+    + ''
+      substituteInPlace solvers/CMakeLists.txt \
+        --replace-fail "$""{Python_SITEARCH}" "${python.sitePackages}"
+    ''
+    # The C++ test suite unconditionally fetches googletest over the network and
+    # is not run here (it requires a GPU); drop it.
+    + ''
+      substituteInPlace CMakeLists.txt \
+        --replace-fail "add_subdirectory(tests/cpp)" ""
+    '';
+
+  build-system = [
+    cmake
+    nanobind
+    setuptools
+  ];
+  dontUseCmakeConfigure = true;
+
+  nativeBuildInputs = [
+    autoAddDriverRunpath
+    cudaPackages.cuda_nvcc
+  ];
+
+  cmakeFlags = [
+    (lib.cmakeFeature "FETCHCONTENT_SOURCE_DIR_UAMMD" uammd-src.outPath)
+    (lib.cmakeFeature "nanobind_DIR" "${nanobind}/${python.sitePackages}/nanobind/cmake")
+  ];
+
+  env = {
+    CMAKE_CUDA_ARCHITECTURES = cudaPackages.flags.cmakeCudaArchitecturesString;
+  };
+
+  preBuild = ''
+    export BUILD_JOBS="$NIX_BUILD_CORES"
+  '';
+
+  buildInputs = [
+    blas
+    lapack
+  ]
+  ++ (with cudaPackages; [
+    cuda_cccl # <nv/target>
+    cuda_cudart # CUDA::cuda_driver (driver stub)
+    libcublas
+    libcufft
+    libcurand
+    libcusolver
+  ]);
+
+  dependencies = [
+    numpy
+    scipy
+  ];
+
+  pythonImportsCheck = [ "libMobility" ];
+
+  nativeCheckInputs = [
+    pytest-xdist
+    pytestCheckHook
+  ];
+
+  disabledTests = [
+    # FileNotFoundError: [Errno 2] No such file or directory: './ref/pair_mobility_nbody_freespace.npz'
+    "test_pair_mobility_angular_nbody"
+
+    # AssertionError (numerical assertion)
+    "test_deterministic_divM_matches_rfd"
+    "test_non_square_box"
+
+    # TypeError: Iterator operand 1 dtype could not be cast from dtype('complex128') to
+    # dtype('float64') according to the rule 'safe'
+    "test_fluctuation_dissipation_angular_displacements"
+
+    # Extremely long
+    "test_fluctuation_dissipation_linear_displacements"
+  ];
+
+  # Tests require GPU access
+  doCheck = false;
+  passthru.gpuCheck = libmobility.overridePythonAttrs {
+    requiredSystemFeatures = [ "cuda" ];
+    doCheck = true;
+  };
+
+  meta = {
+    description = "Python interface to a collection of GPU hydrodynamic mobility solvers";
+    homepage = "https://github.com/stochasticHydroTools/libMobility";
+    changelog = "https://github.com/stochasticHydroTools/libMobility/releases/tag/${finalAttrs.src.tag}";
+    license = lib.licenses.mit;
+    maintainers = with lib.maintainers; [ GaetanLepage ];
+    platforms = lib.platforms.linux;
+    broken = !config.cudaSupport;
+  };
+})
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 0b679e3516fd..ec921baa61cb 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -8897,6 +8897,8 @@ self: super: with self; {
 
   libmambapy = callPackage ../development/python-modules/libmambapy { };
 
+  libmobility = callPackage ../development/python-modules/libmobility { };
+
   libmodulemd = lib.pipe pkgs.libmodulemd [
     toPythonModule
     (