diff --git a/pkgs/development/libraries/quarto/default.nix b/pkgs/development/libraries/quarto/default.nix
index 9daf80dd746c..3ad569f807ff 100644
--- a/pkgs/development/libraries/quarto/default.nix
+++ b/pkgs/development/libraries/quarto/default.nix
@@ -18,6 +18,24 @@
   sysctl,
   which,
 }:
+
+let
+  rWithPackages = rWrapper.override {
+    packages = [
+      rPackages.rmarkdown
+    ] ++ extraRPackages;
+  };
+
+  pythonWithPackages = python3.withPackages (
+    ps:
+    with ps;
+    [
+      jupyter
+      ipython
+    ]
+    ++ (extraPythonPackages ps)
+  );
+in
 stdenv.mkDerivation (final: {
   pname = "quarto";
   version = "1.7.30";
@@ -40,30 +58,13 @@ stdenv.mkDerivation (final: {
 
   preFixup = ''
     wrapProgram $out/bin/quarto \
-      --prefix QUARTO_DENO : ${lib.getExe deno} \
-      --prefix QUARTO_PANDOC : ${lib.getExe pandoc} \
-      --prefix QUARTO_ESBUILD : ${lib.getExe esbuild} \
-      --prefix QUARTO_DART_SASS : ${lib.getExe dart-sass} \
-      --prefix QUARTO_TYPST : ${lib.getExe typst} \
-      ${
-        lib.optionalString (rWrapper != null)
-          "--prefix QUARTO_R : ${
-            rWrapper.override { packages = [ rPackages.rmarkdown ] ++ extraRPackages; }
-          }/bin/R"
-      } \
-      ${lib.optionalString (python3 != null)
-        "--prefix QUARTO_PYTHON : ${
-          python3.withPackages (
-            ps:
-            with ps;
-            [
-              jupyter
-              ipython
-            ]
-            ++ (extraPythonPackages ps)
-          )
-        }/bin/python3"
-      }
+      --set QUARTO_DENO ${lib.getExe deno} \
+      --set QUARTO_PANDOC ${lib.getExe pandoc} \
+      --set QUARTO_ESBUILD ${lib.getExe esbuild} \
+      --set QUARTO_DART_SASS ${lib.getExe dart-sass} \
+      --set QUARTO_TYPST ${lib.getExe typst} \
+      ${lib.optionalString (rWrapper != null) "--set QUARTO_R ${rWithPackages}/bin/R"} \
+      ${lib.optionalString (python3 != null) "--set QUARTO_PYTHON ${pythonWithPackages}/bin/python3"}
   '';
 
   installPhase = ''