diff --git a/pkgs/development/python-modules/guestfs/default.nix b/pkgs/development/python-modules/guestfs/default.nix
index fd236d63c444..020809959b5f 100644
--- a/pkgs/development/python-modules/guestfs/default.nix
+++ b/pkgs/development/python-modules/guestfs/default.nix
@@ -1,5 +1,6 @@
 {
   lib,
+  pythonAtLeast,
   buildPythonPackage,
   fetchurl,
   libguestfs,
@@ -11,6 +12,10 @@ buildPythonPackage rec {
   version = "1.40.2";
   format = "setuptools";
 
+  # FIXME: "error: implicit declaration of function 'PyEval_ThreadsInitialized'"
+  # https://bugzilla.redhat.com/show_bug.cgi?id=2343777
+  disabled = pythonAtLeast "3.13";
+
   src = fetchurl {
     url = "http://download.libguestfs.org/python/guestfs-${version}.tar.gz";
     hash = "sha256-GCKwkhrIXPz0hPrwe3YrhlEr6TuDYQivDzpMlZ+CAzI=";