diff --git a/pkgs/development/tools/wasmedge/default.nix b/pkgs/development/tools/wasmedge/default.nix
index 6f5d9162c5b7..077042b1c0ac 100644
--- a/pkgs/development/tools/wasmedge/default.nix
+++ b/pkgs/development/tools/wasmedge/default.nix
@@ -5,9 +5,15 @@
 , cmake
 , gtest
 , spdlog
+, libxml2
+, libffi
+, Foundation
 }:
 
-llvmPackages.stdenv.mkDerivation rec {
+let
+  stdenv = llvmPackages.stdenv;
+in
+stdenv.mkDerivation rec {
   pname = "wasmedge";
   version = "0.11.2";
 
@@ -18,19 +24,26 @@ llvmPackages.stdenv.mkDerivation rec {
     sha256 = "sha256-P2Y2WK6G8aEK1Q4hjrS9X+2WbOfy4brclB/+SWP5LTM=";
   };
 
+  nativeBuildInputs = [
+    cmake
+    llvmPackages.lld
+  ];
+
   buildInputs = [
     boost
     spdlog
     llvmPackages.llvm
+    libxml2
+    libffi
+  ] ++ lib.optionals stdenv.isDarwin [
+    Foundation
   ];
 
-  nativeBuildInputs = [ cmake llvmPackages.lld ];
-
-  nativeCheckInputs = [ gtest ];
-
   cmakeFlags = [
     "-DCMAKE_BUILD_TYPE=Release"
     "-DWASMEDGE_BUILD_TESTS=OFF" # Tests are downloaded using git
+  ] ++ lib.optionals stdenv.isDarwin [
+    "-DWASMEDGE_FORCE_DISABLE_LTO=ON"
   ];
 
   meta = with lib; {
@@ -38,5 +51,7 @@ llvmPackages.stdenv.mkDerivation rec {
     license = with licenses; [ asl20 ];
     description = "A lightweight, high-performance, and extensible WebAssembly runtime for cloud native, edge, and decentralized applications";
     maintainers = with maintainers; [ dit7ya ];
+    # error: no member named 'utimensat' in the global namespace
+    broken = stdenv.isDarwin && stdenv.isx86_64;
   };
 }
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index c6bd0e392d23..9af1b242c433 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -13073,6 +13073,7 @@ with pkgs;
 
   wasmedge = callPackage ../development/tools/wasmedge {
     llvmPackages = llvmPackages_12;
+    inherit (darwin.apple_sdk.frameworks) Foundation;
   };
 
   welkin = callPackage ../tools/graphics/welkin {};