diff --git a/pkgs/development/python-modules/pyhepmc/default.nix b/pkgs/development/python-modules/pyhepmc/default.nix
new file mode 100644
index 000000000000..966c4ceaf885
--- /dev/null
+++ b/pkgs/development/python-modules/pyhepmc/default.nix
@@ -0,0 +1,65 @@
+{ lib
+, buildPythonPackage
+, fetchFromGitHub
+, cmake
+, setuptools
+, setuptools-scm
+, numpy
+, pybind11
+, wheel
+, pytestCheckHook
+, graphviz
+}:
+
+buildPythonPackage rec {
+  pname = "pyhepmc";
+  version = "2.12.0";
+  format = "pyproject";
+
+  src = fetchFromGitHub {
+    owner = "scikit-hep";
+    repo = pname;
+    rev = "refs/tags/v${version}";
+    hash = "sha256-po1ad02dpY69RRhaRApskH6tdOaSIsCl5PgpjsAzyKo=";
+    fetchSubmodules = true;
+  };
+
+  nativeBuildInputs = [
+    cmake
+    setuptools
+    setuptools-scm
+    wheel
+  ];
+
+  buildInputs = [
+    pybind11
+  ];
+
+  propagatedBuildInputs = [
+    numpy
+  ];
+
+  dontUseCmakeConfigure = true;
+
+  SETUPTOOLS_SCM_PRETEND_VERSION = version;
+  CMAKE_ARGS = [ "-DEXTERNAL_PYBIND11=ON" ];
+
+  preBuild = ''
+    export CMAKE_BUILD_PARALLEL_LEVEL="$NIX_BUILD_CORES"
+  '';
+
+  nativeCheckInputs = [
+    graphviz
+    pytestCheckHook
+  ];
+
+  pythonImportsCheck = [ "pyhepmc" ];
+
+  meta = {
+    description = "Easy-to-use Python bindings for HepMC3";
+    homepage = "https://github.com/scikit-hep/pyhepmc";
+    license = lib.licenses.bsd3;
+    maintainers = with lib.maintainers; [ veprbl ];
+  };
+}
+
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 0b7903ad75d1..e198ab65b40d 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -8190,6 +8190,8 @@ self: super: with self; {
 
   pyheos = callPackage ../development/python-modules/pyheos { };
 
+  pyhepmc = callPackage ../development/python-modules/pyhepmc { };
+
   pyhiveapi = callPackage ../development/python-modules/pyhiveapi { };
 
   pyhumps = callPackage ../development/python-modules/pyhumps { };