diff --git a/pkgs/development/python-modules/manticore/default.nix b/pkgs/development/python-modules/manticore/default.nix
deleted file mode 100644
index 8bc54fabf184..000000000000
--- a/pkgs/development/python-modules/manticore/default.nix
+++ /dev/null
@@ -1,136 +0,0 @@
-{ lib
-, buildPythonPackage
-, capstone
-, crytic-compile
-, fetchFromGitHub
-, intervaltree
-, ply
-, prettytable
-, protobuf
-, pyelftools
-, pyevmasm
-, pysha3
-, pytestCheckHook
-, pythonOlder
-, pyyaml
-, rlp
-, stdenv
-, unicorn
-, wasm
-, yices
-, z3
-}:
-
-buildPythonPackage rec {
-  pname = "manticore";
-  version = "0.3.7";
-  format = "setuptools";
-
-  disabled = pythonOlder "3.7";
-
-  src = fetchFromGitHub {
-    owner = "trailofbits";
-    repo = "manticore";
-    rev = version;
-    hash = "sha256-+17VBfAtkZZIi3SF5Num1Uqg3WjIpgbz3Jx65rD5zkM=";
-  };
-
-  propagatedBuildInputs = [
-    crytic-compile
-    intervaltree
-    ply
-    prettytable
-    protobuf
-    pyevmasm
-    pysha3
-    pyyaml
-    rlp
-    wasm
-  ] ++ lib.optionals (stdenv.isLinux) [
-    capstone
-    pyelftools
-    unicorn
-  ];
-
-  postPatch = ''
-    # Python API is not used in the code, only z3 from PATH
-    substituteInPlace setup.py \
-      --replace "z3-solver" "" \
-      --replace "crytic-compile==0.2.2" "crytic-compile>=0.2.2"
-  '';
-
-  nativeCheckInputs = [
-    pytestCheckHook
-  ];
-
-  preCheck = ''
-    export PATH=${yices}/bin:${z3}/bin:$PATH
-  '';
-
-  disabledTestPaths = [
-    "tests/ethereum" # Enable when solc works again
-    "tests/ethereum_bench"
-  ] ++ lib.optionals (!stdenv.isLinux) [
-    "tests/native"
-    "tests/other/test_locking.py"
-    "tests/other/test_state_introspection.py"
-  ];
-
-  disabledTests = [
-    # Failing tests
-    "test_chmod"
-    "test_timeout"
-    "test_wasm_main"
-    # Slow tests
-    "testmprotectFailSymbReading"
-    "test_ConstraintsForking"
-    "test_resume"
-    "test_symbolic"
-    "test_symbolic_syscall_arg"
-    "test_state_merging"
-    "test_decree"
-    "test_register_comparison"
-    "test_arguments_assertions_armv7"
-    "test_integration_basic_stdout"
-    "test_fclose_linux_amd64"
-    "test_fileio_linux_amd64"
-    "test_arguments_assertions_amd64"
-    "test_ioctl_bogus"
-    "test_ioctl_socket"
-    "test_brk_regression"
-    "test_basic_arm"
-    "test_logger_verbosity"
-    "test_profiling_data"
-    "test_integration_basic_stdin"
-    "test_getchar"
-    "test_ccmp_reg"
-    "test_ld1_mlt_structs"
-    "test_ccmp_imm"
-    "test_try_to_allocate_greater_than_last_space_memory_page_12"
-    "test_not_enough_memory_page_12"
-    "test_PCMPISTRI_30_symbolic"
-    "test_ld1_mlt_structs"
-    "test_time"
-    "test_implicit_call"
-    "test_trace"
-    "test_plugin"
-    # Tests are failing with latest unicorn
-    "Aarch64UnicornInstructions"
-    "test_integration_resume"
-  ];
-
-  pythonImportsCheck = [
-    "manticore"
-  ];
-
-  meta = with lib; {
-    # m.c.manticore:WARNING: Manticore is only supported on Linux. Proceed at your own risk!
-    broken = (stdenv.isLinux && stdenv.isAarch64) || stdenv.isDarwin;
-    description = "Symbolic execution tool for analysis of smart contracts and binaries";
-    homepage = "https://github.com/trailofbits/manticore";
-    changelog = "https://github.com/trailofbits/manticore/releases/tag/${version}";
-    license = licenses.agpl3Only;
-    platforms = platforms.unix;
-    maintainers = with maintainers; [ arturcygan ];
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index 882c75b9aed8..08f14364af15 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -160,6 +160,7 @@ mapAliases ({
   mailman = throw "Please use pkgs.mailman"; # added 2022-04-29
   mailman-hyperkitty = throw "Please use pkgs.mailmanPackages.mailman-hyperkitty"; # added 2022-04-29
   mailman-web = throw "Please use pkgs.mailman-web"; # added 2022-04-29
+  manticore = throw "manticore has been removed because its dependency wasm no longer builds and is unmaintained"; # added 2023-05-20
   mistune_0_8 = throw "mistune_0_8 was removed because it was outdated and insecure"; # added 2022-08-12
   mistune_2_0 = mistune; # added 2022-08-12
   mox = throw "mox was removed because it is unmaintained"; # added 2023-02-21
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 9f2309f864cf..787daef23160 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -5966,10 +5966,6 @@ self: super: with self; {
 
   manuel = callPackage ../development/python-modules/manuel { };
 
-  manticore = callPackage ../development/python-modules/manticore {
-    inherit (pkgs) z3;
-  };
-
   mapbox = callPackage ../development/python-modules/mapbox { };
 
   mapbox-earcut = callPackage ../development/python-modules/mapbox-earcut { };