diff --git a/pkgs/development/python-modules/matplotlib/darwin-sandbox-crash.patch b/pkgs/development/python-modules/matplotlib/darwin-sandbox-crash.patch
deleted file mode 100644
index 883f1edc8be0..000000000000
--- a/pkgs/development/python-modules/matplotlib/darwin-sandbox-crash.patch
+++ /dev/null
@@ -1,14 +0,0 @@
---- a/lib/matplotlib/font_manager.py
-+++ b/lib/matplotlib/font_manager.py
-@@ -266,8 +266,11 @@ def _get_fontconfig_fonts():
- @lru_cache
- def _get_macos_fonts():
-     """Cache and list the font paths known to ``system_profiler SPFontsDataType``."""
--    d, = plistlib.loads(
--        subprocess.check_output(["system_profiler", "-xml", "SPFontsDataType"]))
-+    try:
-+        d, = plistlib.loads(
-+            subprocess.check_output(["system_profiler", "-xml", "SPFontsDataType"]))
-+    except (OSError, subprocess.CalledProcessError, plistlib.InvalidFileException):
-+        return []
-     return [Path(entry["path"]) for entry in d["_items"]]
diff --git a/pkgs/development/python-modules/matplotlib/default.nix b/pkgs/development/python-modules/matplotlib/default.nix
index 9282fe02f30f..2bcf4d246c45 100644
--- a/pkgs/development/python-modules/matplotlib/default.nix
+++ b/pkgs/development/python-modules/matplotlib/default.nix
@@ -100,12 +100,6 @@ buildPythonPackage rec {
     hash = "sha256-3gaxm425XdM9DcF8kmx8nr7Z9XIHS2+sT2UGimgU0BA=";
   };
 
-  patches = lib.optionals stdenv.isDarwin [
-    # Don't crash when running in Darwin sandbox
-    # Submitted upstream: https://github.com/matplotlib/matplotlib/pull/28498
-    ./darwin-sandbox-crash.patch
-  ];
-
   env.XDG_RUNTIME_DIR = "/tmp";
 
   # Matplotlib tries to find Tcl/Tk by opening a Tk window and asking the