diff --git a/maintainers/maintainer-list.nix b/maintainers/maintainer-list.nix
index d0440772467d..09a2d77eebc9 100644
--- a/maintainers/maintainer-list.nix
+++ b/maintainers/maintainer-list.nix
@@ -18265,6 +18265,12 @@
     githubId = 16974598;
     name = "Mike Playle";
   };
+  mkannwischer = {
+    email = "matthias@kannwischer.eu";
+    github = "mkannwischer";
+    githubId = 3984960;
+    name = "Matthias Kannwischer";
+  };
   mkez = {
     email = "matias+nix@zwinger.fi";
     github = "mk3z";
diff --git a/pkgs/by-name/or/or-tools/package.nix b/pkgs/by-name/or/or-tools/package.nix
index 90754354a478..eb312fbff8cc 100644
--- a/pkgs/by-name/or/or-tools/package.nix
+++ b/pkgs/by-name/or/or-tools/package.nix
@@ -137,6 +137,8 @@ stdenv.mkDerivation (finalAttrs: {
   ]
   ++ lib.optionals stdenv.hostPlatform.isDarwin [
     (lib.cmakeBool "CMAKE_MACOSX_RPATH" false)
+    (lib.cmakeFeature "CMAKE_INSTALL_NAME_DIR" "${placeholder "out"}/lib")
+    (lib.cmakeBool "CMAKE_BUILD_WITH_INSTALL_NAME_DIR" true)
   ];
 
   strictDeps = true;
diff --git a/pkgs/by-name/sl/slothy/package.nix b/pkgs/by-name/sl/slothy/package.nix
new file mode 100644
index 000000000000..a07c0bb41594
--- /dev/null
+++ b/pkgs/by-name/sl/slothy/package.nix
@@ -0,0 +1,8 @@
+{ python3Packages }:
+
+(python3Packages.toPythonApplication python3Packages.slothy).overrideAttrs (old: {
+  __structuredAttrs = true;
+  meta = old.meta // {
+    mainProgram = "slothy-cli";
+  };
+})
diff --git a/pkgs/development/python-modules/ortools/default.nix b/pkgs/development/python-modules/ortools/default.nix
new file mode 100644
index 000000000000..7a5a3d7169bf
--- /dev/null
+++ b/pkgs/development/python-modules/ortools/default.nix
@@ -0,0 +1,45 @@
+{
+  lib,
+  buildPythonPackage,
+  lndir,
+  or-tools,
+  immutabledict,
+  numpy,
+  pandas,
+  protobuf,
+}:
+
+buildPythonPackage {
+  pname = "ortools";
+  inherit (or-tools) version;
+  format = "other";
+
+  src = or-tools.python;
+
+  dontBuild = true;
+
+  nativeBuildInputs = [ lndir ];
+
+  installPhase = ''
+    runHook preInstall
+    mkdir -p $out
+    lndir -silent $src $out
+    runHook postInstall
+  '';
+
+  propagatedBuildInputs = [
+    immutabledict
+    numpy
+    pandas
+    protobuf
+  ];
+
+  pythonImportsCheck = [
+    "ortools"
+    "ortools.sat.python.cp_model"
+  ];
+
+  meta = or-tools.meta // {
+    description = "Python bindings for Google's or-tools";
+  };
+}
diff --git a/pkgs/development/python-modules/slothy/default.nix b/pkgs/development/python-modules/slothy/default.nix
new file mode 100644
index 000000000000..f3e9b53ede81
--- /dev/null
+++ b/pkgs/development/python-modules/slothy/default.nix
@@ -0,0 +1,66 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchFromGitHub,
+  setuptools,
+  gcc,
+  llvm,
+  ortools,
+  sympy,
+  unicorn,
+}:
+
+buildPythonPackage rec {
+  pname = "slothy";
+  version = "0.2.0";
+  pyproject = true;
+
+  src = fetchFromGitHub {
+    owner = "slothy-optimizer";
+    repo = "slothy";
+    tag = version;
+    hash = "sha256-1seD/wqAyEcv5HJFO8j53ARd64fddGropA6xk0dq2yk=";
+  };
+
+  build-system = [ setuptools ];
+
+  dependencies = [
+    ortools
+    sympy
+    unicorn
+  ];
+
+  # slothy shells out to `gcc` and the llvm binutils at runtime; extend
+  # PATH at import time so the library works in a plain withPackages env.
+  postPatch = ''
+      substituteInPlace slothy/__init__.py \
+        --replace-fail 'from slothy.core.slothy import Slothy' \
+          'import os
+    os.environ["PATH"] = "${
+      lib.makeBinPath [
+        gcc
+        llvm
+      ]
+    }" + os.pathsep + os.environ.get("PATH", "")
+    from slothy.core.slothy import Slothy'
+  '';
+
+  pythonRelaxDeps = true;
+
+  pythonImportsCheck = [ "slothy" ];
+
+  installCheckPhase = ''
+    runHook preInstallCheck
+    python3 test.py --silent --tests aarch64_simple0_a55
+    runHook postInstallCheck
+  '';
+
+  meta = {
+    description = "Assembly superoptimization via constraint solving";
+    homepage = "https://slothy-optimizer.github.io/slothy";
+    changelog = "https://github.com/slothy-optimizer/slothy/releases/tag/${version}";
+    license = lib.licenses.mit;
+    maintainers = with lib.maintainers; [ mkannwischer ];
+    platforms = lib.platforms.linux ++ lib.platforms.darwin;
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index a18a31464372..cbf531436b00 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -12040,7 +12040,9 @@ self: super: with self; {
 
   ormsgpack = callPackage ../development/python-modules/ormsgpack { };
 
-  ortools = (toPythonModule (pkgs.or-tools.override { python3 = self.python; })).python;
+  ortools = callPackage ../development/python-modules/ortools {
+    or-tools = pkgs.or-tools.override { python3 = self.python; };
+  };
 
   oru = callPackage ../development/python-modules/oru { };
 
@@ -18136,6 +18138,8 @@ self: super: with self; {
 
   slob = callPackage ../development/python-modules/slob { };
 
+  slothy = callPackage ../development/python-modules/slothy { };
+
   slovnet = callPackage ../development/python-modules/slovnet { };
 
   slowapi = callPackage ../development/python-modules/slowapi { };