diff --git a/pkgs/by-name/ch/chez/package.nix b/pkgs/by-name/ch/chez/package.nix
index 7cfb7e682c43..42035a6a82ba 100644
--- a/pkgs/by-name/ch/chez/package.nix
+++ b/pkgs/by-name/ch/chez/package.nix
@@ -1,26 +1,54 @@
 {
   lib,
   stdenv,
-  fetchurl,
-  coreutils,
+  fetchFromGitHub,
+  zuo,
+  zlib,
+  lz4,
+  libffi,
   cctools,
   darwin,
   ncurses,
   libiconv,
   libX11,
-  libuuid,
   testers,
-}@args:
+  writableTmpDirAsHomeHook,
+  buildPackages,
+}:
+let
+  inherit (stdenv.hostPlatform) extensions;
 
+  arch =
+    {
+      "x86_64-linux" = "ta6le";
+      "x86-linux" = "ti3le";
+      "aarch64-linux" = "tarm64le";
+      "x86_64-darwin" = "ta6osx";
+      "aarch64-darwin" = "tarm64osx";
+      "x86_64-windows" = "ta6nt";
+      "aarch64-windows" = "tarm64nt";
+    }
+    .${stdenv.hostPlatform.system}
+      or (throw "Unsupported host system, try checking https://cisco.github.io/ChezScheme/release_notes/latest/release_notes.html to see if ${stdenv.hostPlatform.system} is supported");
+in
 stdenv.mkDerivation (finalAttrs: {
   pname = "chez-scheme";
   version = "10.2.0";
 
-  src = fetchurl {
-    url = "https://github.com/cisco/ChezScheme/releases/download/v${finalAttrs.version}/csv${finalAttrs.version}.tar.gz";
-    hash = "sha256-t5WRbUz+1ZJAxfRLG1B6hlfv0o5i5y4TTQNIbp8+N0o=";
+  src = fetchFromGitHub {
+    owner = "cisco";
+    repo = "ChezScheme";
+    tag = "v${finalAttrs.version}";
+    hash = "sha256-wAEnuC6hktCK/l00G48jYD9fwdyiXkzHjC2YYVeCJXo=";
+    # Vendored nanopass and stex
+    fetchSubmodules = true;
   };
 
+  strictDeps = true;
+  depsBuildBuild = [
+    zuo # Used as the build driver
+    buildPackages.stdenv.cc # Needed for cross
+  ];
   nativeBuildInputs =
     lib.optionals stdenv.hostPlatform.isDarwin [
       cctools
@@ -28,42 +56,54 @@ stdenv.mkDerivation (finalAttrs: {
     ++ lib.optionals (stdenv.hostPlatform.isDarwin && stdenv.hostPlatform.isAarch64) [
       darwin.autoSignDarwinBinariesHook
     ];
+
   buildInputs = [
     ncurses
     libiconv
+    zlib
+    lz4
+    libffi
+  ]
+  ++ lib.optionals stdenv.hostPlatform.isUnix [
     libX11
-    libuuid
   ];
 
-  enableParallelBuilding = true;
-
-  env.NIX_CFLAGS_COMPILE = lib.optionalString stdenv.cc.isGNU "-Wno-error=format-truncation";
-
   /*
-    ** We have to fix a few occurrences to tools with absolute
-    ** paths in some helper scripts, otherwise the build will fail on
-    ** NixOS or in any chroot build.
-  */
-  patchPhase = ''
-    substituteInPlace ./makefiles/installsh \
-      --replace-warn "/usr/bin/true" "${coreutils}/bin/true"
-
-    substituteInPlace zlib/configure \
-      --replace-warn "/usr/bin/libtool" libtool
-  '';
-
-  /*
-    ** Don't use configureFlags, since that just implicitly appends
-    ** everything onto a --prefix flag, which ./configure gets very angry
-    ** about.
+    ** Set to use Nixpkgs dependencies when possible
+    ** instead of vendored dependencies.
     **
-    ** Also, carefully set a manual workarea argument, so that we
+    ** Carefully set a manual workarea argument, so that we
     ** can later easily find the machine type that we built Chez
     ** for.
   */
-  configurePhase = ''
-    ./configure --as-is --threads --installprefix=$out --installman=$out/share/man
-  '';
+  enableParallelBuilding = true;
+  dontAddPrefix = true;
+  configurePlatforms = [ ]; # So it doesn't add the default --build --host flags
+  configureFlags = [
+    # Skip submodule update
+    "--as-is"
+    # Threaded version
+    "--threads"
+    "--installprefix=${placeholder "out"}"
+    "--installman=${placeholder "out"}/share/man"
+    "--enable-libffi"
+    "CC_FOR_BUILD=cc"
+    # Use Nixpkgs dependencies
+    "ZUO=zuo"
+    "ZLIB=${zlib}/lib/libz${extensions.sharedLibrary}"
+    "LZ4=${lz4.lib}/lib/liblz4${extensions.sharedLibrary}"
+    # Append to CFLAGS or else get errors
+    # Don't set CFLAGS so it can do some detections stuff
+    "CFLAGS+=${lib.optionalString stdenv.cc.isGNU "-Wno-error=format-truncation"}"
+  ]
+  ++ lib.optionals (stdenv.hostPlatform != stdenv.buildPlatform) [
+    "--cross"
+    "-m=${arch}"
+  ];
+
+  enableParallelChecking = true;
+  nativeCheckInputs = [ writableTmpDirAsHomeHook ];
+  doCheck = false; # Filesystem checks are impure
 
   # ** Clean up some of the examples from the build output.
   postInstall = ''
@@ -72,18 +112,20 @@ stdenv.mkDerivation (finalAttrs: {
 
   setupHook = ./setup-hook.sh;
 
-  passthru.tests = {
-    version = testers.testVersion {
-      package = finalAttrs.finalPackage;
-    };
+  passthru.tests.version = testers.testVersion {
+    package = finalAttrs.finalPackage;
   };
 
   meta = {
     description = "Powerful and incredibly fast R6RS Scheme compiler";
     homepage = "https://cisco.github.io/ChezScheme/";
+    changelog = "https://cisco.github.io/ChezScheme/release_notes/v${finalAttrs.version}/release_notes.html";
     license = lib.licenses.asl20;
-    maintainers = with lib.maintainers; [ thoughtpolice ];
-    platforms = lib.platforms.unix;
+    maintainers = with lib.maintainers; [
+      thoughtpolice
+      RossSmyth
+    ];
+    platforms = lib.platforms.all;
     mainProgram = "scheme";
   };
 })