diff --git a/pkgs/development/python-modules/pyspx/default.nix b/pkgs/development/python-modules/pyspx/default.nix
new file mode 100644
index 000000000000..b8e3cb49df6f
--- /dev/null
+++ b/pkgs/development/python-modules/pyspx/default.nix
@@ -0,0 +1,47 @@
+{ lib
+, buildPythonPackage
+, cffi
+, fetchFromGitHub
+, pytestCheckHook
+, pythonOlder
+, setuptools
+, wheel
+}:
+
+buildPythonPackage rec {
+  pname = "pyspx";
+  version = "0.5.2";
+  pyproject = true;
+
+  disabled = pythonOlder "3.7";
+
+  src = fetchFromGitHub {
+    owner = "sphincs";
+    repo = "pyspx";
+    rev = "refs/tags/v${version}";
+    hash = "sha256-hMZ7JZoo5RdUwQYpGjtZznH/O6rBUXv+svfOAI0cjqs=";
+    fetchSubmodules = true;
+  };
+
+  nativeBuildInputs = [
+    cffi
+    setuptools
+    wheel
+  ];
+
+  nativeCheckInputs = [
+    pytestCheckHook
+  ];
+
+  pythonImportsCheck = [
+    "pyspx"
+  ];
+
+  meta = with lib; {
+    description = "Python bindings for SPHINCS";
+    homepage = "https://github.com/sphincs/pyspx";
+    changelog = "https://github.com/sphincs/pyspx/releases/tag/v${version}";
+    license = licenses.cc0;
+    maintainers = with maintainers; [ fab ];
+  };
+}
diff --git a/pkgs/development/python-modules/securesystemslib/default.nix b/pkgs/development/python-modules/securesystemslib/default.nix
new file mode 100644
index 000000000000..4a0ce694866b
--- /dev/null
+++ b/pkgs/development/python-modules/securesystemslib/default.nix
@@ -0,0 +1,96 @@
+{ lib
+, asn1crypto
+, azure-identity
+, azure-keyvault-keys
+, boto3
+, botocore
+, buildPythonPackage
+, cryptography
+, ed25519
+, fetchFromGitHub
+, google-cloud-kms
+, hatchling
+, pynacl
+, pyspx
+, pytestCheckHook
+, pythonOlder
+}:
+
+buildPythonPackage rec {
+  pname = "securesystemslib";
+  version = "0.30.0";
+  pyproject = true;
+
+  disabled = pythonOlder "3.8";
+
+  src = fetchFromGitHub {
+    owner = "secure-systems-lab";
+    repo = "securesystemslib";
+    rev = "refs/tags/v${version}";
+    hash = "sha256-Jqw65VTMLA/X7VQGxN0BlTzF/lxBYirDKBf+xI9cfhg=";
+  };
+
+  nativeBuildInputs = [
+    hatchling
+  ];
+
+  passthru.optional-dependencies = {
+    PySPX = [
+      pyspx
+    ];
+    awskms = [
+      boto3
+      botocore
+      cryptography
+    ];
+    azurekms = [
+      azure-identity
+      azure-keyvault-keys
+      cryptography
+    ];
+    crypto = [
+      cryptography
+    ];
+    gcpkms = [
+      cryptography
+      google-cloud-kms
+    ];
+    hsm = [
+      asn1crypto
+      cryptography
+    #   pykcs11
+    ];
+    pynacl = [
+      pynacl
+    ];
+    # Circular dependency
+    # sigstore = [
+    #   sigstore
+    # ];
+  };
+
+  nativeCheckInputs = [
+    ed25519
+    pytestCheckHook
+  ] ++ lib.flatten (builtins.attrValues passthru.optional-dependencies);
+
+  pythonImportsCheck = [
+    "securesystemslib"
+  ];
+
+  disabledTestPaths = [
+    # pykcs11 is not available
+    "tests/test_hsm_signer.py"
+    # Ignore vendorized tests
+    "securesystemslib/_vendor/"
+  ];
+
+  meta = with lib; {
+    description = "Cryptographic and general-purpose routines";
+    homepage = "https://github.com/secure-systems-lab/securesystemslib";
+    changelog = "https://github.com/secure-systems-lab/securesystemslib/blob/${version}/CHANGELOG.md";
+    license = licenses.mit;
+    maintainers = with maintainers; [ fab ];
+  };
+}
+
diff --git a/pkgs/development/python-modules/tuf/default.nix b/pkgs/development/python-modules/tuf/default.nix
new file mode 100644
index 000000000000..b6965a7f42e2
--- /dev/null
+++ b/pkgs/development/python-modules/tuf/default.nix
@@ -0,0 +1,61 @@
+{ lib
+, buildPythonPackage
+, ed25519
+, fetchFromGitHub
+, hatchling
+, pytestCheckHook
+, pythonOlder
+, requests
+, securesystemslib
+}:
+
+buildPythonPackage rec {
+  pname = "tuf";
+  version = "3.1.0";
+  pyproject = true;
+
+  disabled = pythonOlder "3.8";
+
+  src = fetchFromGitHub {
+    owner = "theupdateframework";
+    repo = "python-tuf";
+    rev = "refs/tags/v${version}";
+    hash = "sha256-IGF/8RdX7Oxl6gdqPGN1w/6q4zaei+MnYXBZepB4KUA=";
+  };
+
+  postPatch = ''
+    substituteInPlace pyproject.toml \
+      --replace "hatchling==" "hatchling>="
+  '';
+
+  nativeBuildInputs = [
+    hatchling
+  ];
+
+  propagatedBuildInputs = [
+    requests
+    securesystemslib
+  ] ++ securesystemslib.optional-dependencies.pynacl
+  ++ securesystemslib.optional-dependencies.crypto;
+
+  nativeCheckInputs = [
+    ed25519
+    pytestCheckHook
+  ];
+
+  pythonImportsCheck = [
+    "tuf"
+  ];
+
+  preCheck = ''
+    cd tests
+  '';
+
+  meta = with lib; {
+    description = "Python reference implementation of The Update Framework (TUF)";
+    homepage = "https://github.com/theupdateframework/python-tuf";
+    changelog = "https://github.com/theupdateframework/python-tuf/blob/v${version}/docs/CHANGELOG.md";
+    license = with licenses; [ asl20 mit ];
+    maintainers = with maintainers; [ fab ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index ff9578aaf486..be9abf636e02 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -11102,6 +11102,8 @@ self: super: with self; {
 
   pysptk = callPackage ../development/python-modules/pysptk { };
 
+  pyspx = callPackage ../development/python-modules/pyspx { };
+
   pysqlcipher3 = callPackage ../development/python-modules/pysqlcipher3 {
     inherit (pkgs) sqlcipher;
   };
@@ -12753,6 +12755,8 @@ self: super: with self; {
 
   secure = callPackage ../development/python-modules/secure { };
 
+  securesystemslib = callPackage ../development/python-modules/securesystemslib { };
+
   securetar = callPackage ../development/python-modules/securetar { };
 
   sectools = callPackage ../development/python-modules/sectools { };
@@ -14345,6 +14349,8 @@ self: super: with self; {
 
   tubes = callPackage ../development/python-modules/tubes { };
 
+  tuf = callPackage ../development/python-modules/tuf { };
+
   tunigo = callPackage ../development/python-modules/tunigo { };
 
   tubeup = callPackage ../development/python-modules/tubeup { };