diff --git a/pkgs/development/libraries/physics/lhapdf/default.nix b/pkgs/development/libraries/physics/lhapdf/default.nix
index a3753d86356e..991309b54d46 100644
--- a/pkgs/development/libraries/physics/lhapdf/default.nix
+++ b/pkgs/development/libraries/physics/lhapdf/default.nix
@@ -2,11 +2,11 @@
 
 stdenv.mkDerivation rec {
   pname = "lhapdf";
-  version = "6.4.0";
+  version = "6.5.1";
 
   src = fetchurl {
     url = "https://www.hepforge.org/archive/lhapdf/LHAPDF-${version}.tar.gz";
-    sha256 = "sha256-fS8CZ+LWWw3e4EhVOzQtfIk6bbq+HjJsrWLeABDdgQw=";
+    sha256 = "sha256-ElZBniIn0aT5M4f+HagF5kg1FBfTdV6K9aMKNaamZ1E=";
   };
 
   # The Apple SDK only exports locale_t from xlocale.h whereas glibc
@@ -15,9 +15,16 @@ stdenv.mkDerivation rec {
     substituteInPlace src/GridPDF.cc --replace '#include <locale>' '#include <xlocale.h>'
   '';
 
-  nativeBuildInputs = [ makeWrapper ];
+  nativeBuildInputs = [ makeWrapper ]
+    ++ lib.optionals (python != null && lib.versionAtLeast python.version "3.10") [ python.pkgs.cython ];
   buildInputs = [ python ];
 
+  configureFlags = lib.optionals (python == null) [ "--disable-python" ];
+
+  preBuild = lib.optionalString (python != null && lib.versionAtLeast python.version "3.10") ''
+    rm wrappers/python/lhapdf.cpp
+  '';
+
   enableParallelBuilding = true;
 
   passthru = {
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index a32a9cad0e6e..bf3dc006a77c 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -33191,7 +33191,7 @@ with pkgs;
 
   mcfm = callPackage ../applications/science/physics/MCFM {
     stdenv = gccStdenv;
-    lhapdf = lhapdf.override { stdenv = gccStdenv; };
+    lhapdf = lhapdf.override { stdenv = gccStdenv; python = null; };
   };
 
   nnpdf = callPackage ../applications/science/physics/nnpdf { };