diff --git a/pkgs/development/python-modules/mypy-boto3/default.nix b/pkgs/development/python-modules/mypy-boto3/default.nix
index de52849391ba..7d4d61bee4bb 100644
--- a/pkgs/development/python-modules/mypy-boto3/default.nix
+++ b/pkgs/development/python-modules/mypy-boto3/default.nix
@@ -443,8 +443,8 @@ in
       "sha256-92qhSUqTiLgbtvCdi/Mmgve18mcYR00ABL+bNy7/OnY=";
 
   mypy-boto3-ec2 =
-    buildMypyBoto3Package "ec2" "1.42.38"
-      "sha256-ni/jZ4xTnnVLnPYo7Q4ypDFmGWBySDjjCgLULW0tMr0=";
+    buildMypyBoto3Package "ec2" "1.42.45"
+      "sha256-q3YTS3urB2ZNYiVxJLZOR7fwMhKrq6mLyqBESkfEdiY=";
 
   mypy-boto3-ec2-instance-connect =
     buildMypyBoto3Package "ec2-instance-connect" "1.42.3"