diff --git a/pkgs/desktops/gnome/core/mutter/default.nix b/pkgs/desktops/gnome/core/mutter/default.nix
index b0b8e4ce7e30..91179396048c 100644
--- a/pkgs/desktops/gnome/core/mutter/default.nix
+++ b/pkgs/desktops/gnome/core/mutter/default.nix
@@ -35,6 +35,7 @@
 , libXau
 , libinput
 , libdrm
+, libei
 , gsettings-desktop-schemas
 , glib
 , atk
@@ -66,13 +67,13 @@
 
 stdenv.mkDerivation (finalAttrs: {
   pname = "mutter";
-  version = "45.alpha";
+  version = "45.beta.1";
 
   outputs = [ "out" "dev" "man" "devdoc" ];
 
   src = fetchurl {
     url = "mirror://gnome/sources/mutter/${lib.versions.major finalAttrs.version}/mutter-${finalAttrs.version}.tar.xz";
-    sha256 = "DgyXx8AE+O9asrKugf5/61r/DUR1eRflBZhjNpsizk0=";
+    sha256 = "n5OWijQm4DiCeIo3J7DKZ9zGaKkXddzUeRj5zylcFM4=";
   };
 
   mesonFlags = [
@@ -123,6 +124,7 @@ stdenv.mkDerivation (finalAttrs: {
     harfbuzz
     libcanberra
     libdrm
+    libei
     libgudev
     libinput
     libstartup_notification
@@ -161,6 +163,10 @@ stdenv.mkDerivation (finalAttrs: {
 
   postPatch = ''
     patchShebangs src/backends/native/gen-default-modes.py
+
+    # https://gitlab.gnome.org/GNOME/mutter/-/merge_requests/3142
+    substituteInPlace meson.build \
+      --replace "dependency('sysprof-4')" "dependency('sysprof-6')"
   '';
 
   postInstall = ''