diff --git a/pkgs/by-name/aw/awscli2/package.nix b/pkgs/by-name/aw/awscli2/package.nix
index e24c5e30c75b..0a9958e92d2f 100644
--- a/pkgs/by-name/aw/awscli2/package.nix
+++ b/pkgs/by-name/aw/awscli2/package.nix
@@ -141,6 +141,12 @@ py.pkgs.buildPythonApplication rec {
     export HOME=$(mktemp -d)
   '';
 
+  # Propagating dependencies leaks them through $PYTHONPATH which causes issues
+  # when used in nix-shell.
+  postFixup = ''
+    rm $out/nix-support/propagated-build-inputs
+  '';
+
   pytestFlagsArray = [
     "-Wignore::DeprecationWarning"
   ];