diff --git a/pkgs/development/python-modules/pysparse/default.nix b/pkgs/development/python-modules/pysparse/default.nix
deleted file mode 100644
index 02c1c36d0837..000000000000
--- a/pkgs/development/python-modules/pysparse/default.nix
+++ /dev/null
@@ -1,49 +0,0 @@
-{ lib
-, buildPythonPackage
-, fetchFromGitHub
-, numpy
-, blas
-, lapack
-, isPy27
-, python
-}:
-
-buildPythonPackage {
-  pname = "pysparse";
-  version = "1.3-dev";
-  disabled = !isPy27;
-
-  src = fetchFromGitHub {
-    owner = "PythonOptimizers";
-    repo = "pysparse";
-    rev = "f8430bd99ac2a6209c462657c5792d10033888cc";
-    sha256 = "19xcq8214yndra1xjhna3qjm32wprsqck97dlnw3xcww7rfy6hqh";
-  };
-
-  hardeningDisable = [ "all" ];
-
-  propagatedBuildInputs = [
-    numpy
-    blas
-    lapack
-  ];
-
-  # Include patches from working version of PySparse 1.3-dev in
-  # Conda-Forge,
-  # https://github.com/conda-forge/pysparse-feedstock/tree/b69266911a2/recipe
-  # Thanks to https://github.com/guyer
-  patches = [ ./dropPackageLoader.patch ];
-
-  checkPhase = ''
-    cd test
-    ${python.interpreter} -c "import pysparse"
-    ${python.interpreter} test_sparray.py
-  '';
-
-  meta = with lib; {
-    homepage = "https://github.com/PythonOptimizers/pysparse";
-    description = "A Sparse Matrix Library for Python";
-    license = licenses.bsd3;
-    maintainers = with maintainers; [ costrouc ];
-  };
-}
diff --git a/pkgs/development/python-modules/pysparse/dropPackageLoader.patch b/pkgs/development/python-modules/pysparse/dropPackageLoader.patch
deleted file mode 100644
index b2526645f890..000000000000
--- a/pkgs/development/python-modules/pysparse/dropPackageLoader.patch
+++ /dev/null
@@ -1,88 +0,0 @@
-diff --git a/pysparse/__init__.py b/pysparse/__init__.py
-index 6d09b00..ff39084 100644
---- a/pysparse/__init__.py
-+++ b/pysparse/__init__.py
-@@ -1,9 +1,42 @@
--"PySparse: A Fast Sparse Matrix Library for Python"
-+"""
-+PySparse: A Fast Sparse Matrix Library for Python
-+=================================================
-+
-+Documentation is available in the docstrings and
-+online at http://pysparse.sourceforge.net/.
-+
-+Contents
-+--------
-+Pysparse imports
-+::
-+ spmatrix                     --- sparse matrix types
-+
-+and, in addition, provides:
-+    
-+Subpackages
-+-----------
-+Using any of these subpackages requires an explicit import.  For example,
-+``import pysparse.itsolvers``.
-+
-+::
-+
-+ itsolvers                    --- Iterative linear algebra solvers
-+ precon                       --- Preconditioners
-+ direct                       --- Direct solvers
-+ direct.superlu               --- Wrappers to SuperLU library
-+ direct.umfpack               --- Wrappers to UMFPACK library
-+ eigen.jdsym                  --- Jacobi davidson eigenvalue solver for symmetric matrices
-+ 
-+Utility tools
-+-------------
-+::
-+
-+ __version__       --- pysparse version string
-+"""
-+
- 
- __docformat__ = 'restructuredtext'
- 
--# Imports
--from numpy._import_tools import PackageLoader
- try:
-     from version import version as __version__
- except ImportError:
-@@ -11,31 +44,6 @@ except ImportError:
-     __version__ = 'undefined'
-     
- from sparse import spmatrix
--#from sparse import *
--from misc import get_include
--
--pkgload = PackageLoader()
--pkgload(verbose=False,postpone=True)
--
--if __doc__:
--    __doc__ += """
--
--Available subpackages
-----------------------
--"""
--if __doc__:
--    __doc__ += pkgload.get_pkgdocs()
--
--__all__ = filter(lambda s: not s.startswith('_'), dir())
--__all__ += '__version__'
--
--__doc__ += """
--
--Miscellaneous
---------------
--
--    __version__  :  pysparse version string
--"""
- 
- from pysparse.misc import Deprecated
- 
-@@ -47,3 +55,5 @@ class _superlu:
-         return self.factorizeFnc(*args, **kwargs)
-     
- superlu = _superlu()
-+
-+__all__ = ['spmatrix', 'superlu', '__version__']
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index 045ca9b02f73..6537b06d2686 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -184,6 +184,7 @@ mapAliases ({
   pyroute2-nslink = throw "pyroute2 migrated back to a single package scheme in version 0.7.1"; # added 2022-07-16
   pyroute2-protocols = throw "pyroute2 migrated back to a single package scheme in version 0.7.1"; # added 2022-07-16
   pysmart-smartx = pysmart; # added 2021-10-22
+  pysparse = throw "pysparse has been abandoned upstream."; # added 2023-02-28
   pyspotify = throw "pyspotify has been removed because Spotify stopped supporting libspotify"; # added 2022-05-29
   pytest_6 = pytest; # added 2022-02-10
   pytestcov = pytest-cov; # added 2021-01-04
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 98343756db20..2ede45a6f415 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -8931,8 +8931,6 @@ self: super: with self; {
 
   pyspark = callPackage ../development/python-modules/pyspark { };
 
-  pysparse = callPackage ../development/python-modules/pysparse { };
-
   pyspcwebgw = callPackage ../development/python-modules/pyspcwebgw { };
 
   pyspellchecker = callPackage ../development/python-modules/pyspellchecker { };