diff --git a/pkgs/development/libraries/ffmpeg-full/default.nix b/pkgs/development/libraries/ffmpeg-full/default.nix
index e4a5d908d263..8d2144f10395 100644
--- a/pkgs/development/libraries/ffmpeg-full/default.nix
+++ b/pkgs/development/libraries/ffmpeg-full/default.nix
@@ -1,4 +1,4 @@
-{ lib, stdenv, ffmpeg, addOpenGLRunpath, pkg-config, perl, texinfo, yasm
+{ lib, stdenv, buildPackages, ffmpeg, addOpenGLRunpath, pkg-config, perl, texinfo, yasm
 /*
  *  Licensing options (yes some are listed twice, filters and such are not listed)
  */
@@ -107,7 +107,7 @@
 , opencore-amr ? null # AMR-NB de/encoder & AMR-WB decoder
 #, opencv ? null # Video filtering
 , openglExtlib ? false, libGL ? null, libGLU ? null # OpenGL rendering
-#, openh264 ? null # H.264/AVC encoder
+, openh264 ? null # H.264/AVC encoder
 , openjpeg ? null # JPEG 2000 de/encoder
 , opensslExtlib ? false, openssl ? null
 , libpulseaudio ? null # Pulseaudio input support
@@ -164,7 +164,7 @@
  *
  * Not packaged:
  *   aacplus avisynth cdio-paranoia crystalhd libavc1394 libiec61883
- *   libnut libquvi nvenc opencl openh264 oss shine twolame
+ *   libnut libquvi nvenc opencl oss shine twolame
  *   utvideo vo-aacenc vo-amrwbenc xvmc zvbi blackmagic-design-desktop-video
  *
  * Need fixes to support Darwin:
@@ -260,7 +260,7 @@ stdenv.mkDerivation rec {
 
   configurePlatforms = [];
   configureFlags = [
-    "--target_os=${stdenv.hostPlatform.parsed.kernel.name}"
+    "--target_os=${if stdenv.hostPlatform.isMinGW then "mingw64" else stdenv.hostPlatform.parsed.kernel.name}" #mingw32 and mingw64 doesn't have a difference here, it is internally rewritten as mingw32
     "--arch=${stdenv.hostPlatform.parsed.cpu.name}"
     /*
      *  Licensing flags
@@ -282,7 +282,7 @@ stdenv.mkDerivation rec {
     (enableFeature hardcodedTablesBuild "hardcoded-tables")
     (enableFeature safeBitstreamReaderBuild "safe-bitstream-reader")
     (if multithreadBuild then (
-       if isCygwin then
+       if stdenv.hostPlatform.isWindows then
          "--disable-pthreads --enable-w32threads"
        else # Use POSIX threads by default
          "--enable-pthreads --disable-w32threads")
@@ -382,7 +382,7 @@ stdenv.mkDerivation rec {
     (enableFeature (opencore-amr != null && version3Licensing) "libopencore-amrnb")
     #(enableFeature (opencv != null) "libopencv")
     (enableFeature openglExtlib "opengl")
-    #(enableFeature (openh264 != null) "openh264")
+    (enableFeature (openh264 != null) "libopenh264")
     (enableFeature (openjpeg != null) "libopenjpeg")
     (enableFeature (opensslExtlib && gplLicensing) "openssl")
     (enableFeature (libpulseaudio != null) "libpulse")
@@ -420,6 +420,7 @@ stdenv.mkDerivation rec {
   ] ++ optionals (stdenv.hostPlatform != stdenv.buildPlatform) [
     "--cross-prefix=${stdenv.cc.targetPrefix}"
     "--enable-cross-compile"
+    "--host-cc=${buildPackages.stdenv.cc}/bin/cc"
   ] ++ optionals stdenv.cc.isClang [
     "--cc=clang"
     "--cxx=clang++"
@@ -433,7 +434,7 @@ stdenv.mkDerivation rec {
     libogg libopus librsvg libssh libtheora libvdpau libvorbis libvpx libwebp libX11
     libxcb libXv libXext xz openal openjpeg libpulseaudio rav1e svt-av1 rtmpdump opencore-amr
     samba SDL2 soxr speex srt vid-stab vo-amrwbenc x264 x265 xavs xvidcore
-    zeromq4 zimg zlib
+    zeromq4 zimg zlib openh264
   ] ++ optionals openglExtlib [ libGL libGLU ]
     ++ optionals nonfreeLicensing [ fdk_aac openssl ]
     ++ optional ((isLinux || isFreeBSD) && libva != null) libva
diff --git a/pkgs/development/libraries/gettext/default.nix b/pkgs/development/libraries/gettext/default.nix
index 3f8215d19fc2..22acc73c49c6 100644
--- a/pkgs/development/libraries/gettext/default.nix
+++ b/pkgs/development/libraries/gettext/default.nix
@@ -1,4 +1,4 @@
-{ stdenv, lib, fetchurl, libiconv, xz }:
+{ stdenv, lib, fetchurl, fetchpatch, libiconv, xz }:
 
 # Note: this package is used for bootstrapping fetchurl, and thus
 # cannot use fetchpatch! All mutable patches (generated by GitHub or
@@ -15,7 +15,11 @@ stdenv.mkDerivation rec {
   };
   patches = [
     ./absolute-paths.diff
-  ];
+  ] ++ lib.optional stdenv.hostPlatform.isWindows (fetchpatch {
+    url = "https://aur.archlinux.org/cgit/aur.git/plain/gettext_formatstring-ruby.patch?h=mingw-w64-gettext&id=e8b577ee3d399518d005e33613f23363a7df07ee";
+    name = "gettext_formatstring-ruby.patch";
+    sha256 = "sha256-6SxZObOMkQDxuKJuJY+mQ/VuJJxSeGbf97J8ZZddCV0=";
+  });
 
   outputs = [ "out" "man" "doc" "info" ];
 
diff --git a/pkgs/development/libraries/glib/default.nix b/pkgs/development/libraries/glib/default.nix
index c8138431a0a7..30f43c00a05d 100644
--- a/pkgs/development/libraries/glib/default.nix
+++ b/pkgs/development/libraries/glib/default.nix
@@ -93,6 +93,7 @@ stdenv.mkDerivation rec {
 
   buildInputs = [
     libelf setupHook pcre
+  ] ++ optionals (!stdenv.hostPlatform.isWindows) [
     bash gnum4 # install glib-gettextize and m4 macros for other apps to use
   ] ++ optionals stdenv.isLinux [
     libselinux
@@ -143,6 +144,9 @@ stdenv.mkDerivation rec {
     patchShebangs glib/gen-unicode-tables.pl
     patchShebangs tests/gen-casefold-txt.py
     patchShebangs tests/gen-casemap-txt.py
+  '' + lib.optionalString stdenv.hostPlatform.isWindows ''
+    substituteInPlace gio/win32/meson.build \
+      --replace "libintl, " ""
   '';
 
   DETERMINISTIC_BUILD = 1;
diff --git a/pkgs/development/libraries/openh264/default.nix b/pkgs/development/libraries/openh264/default.nix
index 3858cb4dc2d5..93fc495d3854 100644
--- a/pkgs/development/libraries/openh264/default.nix
+++ b/pkgs/development/libraries/openh264/default.nix
@@ -1,4 +1,4 @@
-{ lib, stdenv, fetchFromGitHub, nasm }:
+{ lib, stdenv, fetchFromGitHub, nasm, windows }:
 
 stdenv.mkDerivation rec {
   pname = "openh264";
@@ -13,10 +13,16 @@ stdenv.mkDerivation rec {
 
   nativeBuildInputs = [ nasm ];
 
+  buildInputs = lib.optional stdenv.hostPlatform.isWindows windows.pthreads;
+
   makeFlags = [
     "PREFIX=${placeholder "out"}"
     "ARCH=${stdenv.hostPlatform.linuxArch}"
-  ];
+  ] ++ lib.optional stdenv.hostPlatform.isWindows "OS=mingw_nt";
+
+  enableParallelBuilding = true;
+
+  hardeningDisable = lib.optional stdenv.hostPlatform.isWindows "stackprotector";
 
   meta = with lib; {
     description = "A codec library which supports H.264 encoding and decoding";
diff --git a/pkgs/development/tools/misc/binutils/default.nix b/pkgs/development/tools/misc/binutils/default.nix
index 0d7ff5a54656..8d759457fa11 100644
--- a/pkgs/development/tools/misc/binutils/default.nix
+++ b/pkgs/development/tools/misc/binutils/default.nix
@@ -94,7 +94,8 @@ stdenv.mkDerivation {
        # indeed GHC will refuse to compile with a binutils suffering from it. See
        # this comment for more information:
        # https://gitlab.haskell.org/ghc/ghc/issues/4210#note_78333
-       lib.optional (stdenv.targetPlatform.isAarch32 && stdenv.hostPlatform.system != stdenv.targetPlatform.system) ./R_ARM_COPY.patch;
+       lib.optional (stdenv.targetPlatform.isAarch32 && stdenv.hostPlatform.system != stdenv.targetPlatform.system) ./R_ARM_COPY.patch
+    ++ lib.optional stdenv.targetPlatform.isWindows ./windres-locate-gcc.patch;
 
   outputs = [ "out" "info" "man" ];
 
diff --git a/pkgs/development/tools/misc/binutils/windres-locate-gcc.patch b/pkgs/development/tools/misc/binutils/windres-locate-gcc.patch
new file mode 100644
index 000000000000..721667c62cec
--- /dev/null
+++ b/pkgs/development/tools/misc/binutils/windres-locate-gcc.patch
@@ -0,0 +1,19 @@
+diff --git a/binutils/resrc.c b/binutils/resrc.c
+index a875c3a4..0411d047 100644
+--- a/binutils/resrc.c
++++ b/binutils/resrc.c
+@@ -521,7 +521,13 @@ read_rc_file (const char *filename, const char *preprocessor,
+ 
+       cpp_pipe = 0;
+ 
+-      if (dash)
++      /* Nixpkgs specific : look first at the prefixed path
++        ( there should be no gcc in the binutils folder ) */
++      if (slash && dash) {
++        cpp_pipe = look_for_default(cmd, slash + 1, dash - slash, preprocargs, filename);
++      }
++
++      if (dash && ! cpp_pipe)
+ 	{
+ 	  /* First, try looking for a prefixed gcc in the windres
+ 	     directory, with the same prefix as windres */