diff --git a/pkgs/development/python-modules/pysam/default.nix b/pkgs/development/python-modules/pysam/default.nix
index cdabdace5294..da739b495b11 100644
--- a/pkgs/development/python-modules/pysam/default.nix
+++ b/pkgs/development/python-modules/pysam/default.nix
@@ -13,11 +13,12 @@
   setuptools,
   samtools,
   zlib,
+  nix-update-script,
 }:
 
-buildPythonPackage {
+buildPythonPackage rec {
   pname = "pysam";
-  version = "0.22.1-unstable-2024-10-30";
+  version = "0.23.3";
   pyproject = true;
 
   # Fetching from GitHub instead of PyPi cause the 0.13 src release on PyPi is
@@ -26,16 +27,19 @@ buildPythonPackage {
   src = fetchFromGitHub {
     owner = "pysam-developers";
     repo = "pysam";
-    rev = "0eae5be21ac3ab3ac7aa770a3931e2977e37b909";
-    hash = "sha256-i8glYSpuCRNhNtK4i6eUrerz8daiMfY/YgDwgSuELbc=";
+    tag = "v${version}";
+    hash = "sha256-yOLnfuGQW+j0nHy4MRlwurZMpeRHTGmQ9eLmihcAGoQ=";
   };
 
-  nativeBuildInputs = [
+  build-system = [
     cython
-    samtools
     setuptools
   ];
 
+  nativeBuildInputs = [
+    samtools
+  ];
+
   buildInputs = [
     bzip2
     curl
@@ -73,11 +77,15 @@ buildPythonPackage {
     "pysam.libchtslib"
     "pysam.libcutils"
     "pysam.libcvcf"
+    "pysam.libcsamtools"
   ];
 
+  passthru.updateScript = nix-update-script { };
+
   meta = {
     description = "Python module for reading, manipulating and writing genome data sets";
     downloadPage = "https://github.com/pysam-developers/pysam";
+    changelog = "https://github.com/pysam-developers/pysam/releases/tag/${src.tag}";
     homepage = "https://pysam.readthedocs.io";
     maintainers = with lib.maintainers; [ unode ];
     license = lib.licenses.mit;