diff --git a/pkgs/development/libraries/protobuf/generic.nix b/pkgs/development/libraries/protobuf/generic.nix
index 0165766f3fa4..11fa9ebff6c1 100644
--- a/pkgs/development/libraries/protobuf/generic.nix
+++ b/pkgs/development/libraries/protobuf/generic.nix
@@ -42,14 +42,23 @@ stdenv.mkDerivation (finalAttrs: {
       --replace-fail 'tmpnam(b)' '"'$TMPDIR'/foo"'
   '';
 
-  patches = lib.optionals (lib.versionOlder version "22") [
-    # fix protobuf-targets.cmake installation paths, and allow for CMAKE_INSTALL_LIBDIR to be absolute
-    # https://github.com/protocolbuffers/protobuf/pull/10090
-    (fetchpatch {
-      url = "https://github.com/protocolbuffers/protobuf/commit/a7324f88e92bc16b57f3683403b6c993bf68070b.patch";
-      hash = "sha256-SmwaUjOjjZulg/wgNmR/F5b8rhYA2wkKAjHIOxjcQdQ=";
-    })
-  ];
+  patches =
+    lib.optionals (lib.versionOlder version "22") [
+      # fix protobuf-targets.cmake installation paths, and allow for CMAKE_INSTALL_LIBDIR to be absolute
+      # https://github.com/protocolbuffers/protobuf/pull/10090
+      (fetchpatch {
+        url = "https://github.com/protocolbuffers/protobuf/commit/a7324f88e92bc16b57f3683403b6c993bf68070b.patch";
+        hash = "sha256-SmwaUjOjjZulg/wgNmR/F5b8rhYA2wkKAjHIOxjcQdQ=";
+      })
+    ]
+    ++ lib.optionals (lib.versions.major version == "29") [
+      # fix temporary directory handling to avoid test failures on darwin
+      # https://github.com/NixOS/nixpkgs/issues/464439
+      (fetchpatch {
+        url = "https://github.com/protocolbuffers/protobuf/commit/0e9d0f6e77280b7a597ebe8361156d6bb1971dca.patch";
+        hash = "sha256-rIP+Ft/SWVwh9Oy8y8GSUBgP6CtLCLvGmr6nOqmyHhY=";
+      })
+    ];
 
   # hook to provide the path to protoc executable, used at build time
   build_protobuf =
@@ -100,6 +109,10 @@ stdenv.mkDerivation (finalAttrs: {
   versionCheckProgramArg = "--version";
   doInstallCheck = true;
 
+  env = lib.optionalAttrs (lib.versions.major version == "29") {
+    GTEST_DEATH_TEST_STYLE = "threadsafe";
+  };
+
   passthru = {
     tests = {
       pythonProtobuf = python3.pkgs.protobuf;