diff --git a/pkgs/development/python-modules/amqplib/default.nix b/pkgs/development/python-modules/amqplib/default.nix
deleted file mode 100644
index 60c66e241491..000000000000
--- a/pkgs/development/python-modules/amqplib/default.nix
+++ /dev/null
@@ -1,31 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  fetchPypi,
-  python,
-}:
-
-buildPythonPackage rec {
-  pname = "amqplib";
-  version = "1.0.2";
-  format = "setuptools";
-
-  src = fetchPypi {
-    inherit pname version;
-    extension = "tgz";
-    sha256 = "843d69b681a60afd21fbf50f310404ec67fcdf9d13dfcf6e9d41f3b456217e5b";
-  };
-
-  # testing assumes network connection
-  doCheck = false;
-
-  checkPhase = ''
-    ${python.interpreter} tests/client_0_8/run_all.py
-  '';
-
-  meta = with lib; {
-    homepage = "https://github.com/barryp/py-amqplib";
-    description = "Python client for the Advanced Message Queuing Procotol (AMQP)";
-    license = licenses.lgpl21;
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index eef36ba408a9..efd944db7137 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -60,6 +60,7 @@ mapAliases {
   abodepy = throw "'abodepy' has been renamed to/replaced by 'jaraco-abode'"; # Converted to throw 2025-10-29
   amazon-kclpy = throw "amazon-kclpy has been removed because it has been marked as broken since at least November 2024."; # Added 2025-10-03
   amazon_kclpy = throw "'amazon_kclpy' has been renamed to/replaced by 'amazon-kclpy'"; # Converted to throw 2025-10-29
+  amqplib = throw "amqplib has been removed as it was unmaintained upstream"; # Added 2025-11-22
   ansiwrap = throw "ansiwrap has been removed because it has been marked as broken since at least November 2024."; # Added 2025-10-03
   apkit = throw "apkit was removed because it is unmaintained upstream and different from apkit on PyPI"; # added 2025-09-13
   APScheduler = throw "'APScheduler' has been renamed to/replaced by 'apscheduler'"; # Converted to throw 2025-10-29
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index cf49f98f3e6a..52102aced862 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -668,8 +668,6 @@ self: super: with self; {
 
   amqp = callPackage ../development/python-modules/amqp { };
 
-  amqplib = callPackage ../development/python-modules/amqplib { };
-
   amqtt = callPackage ../development/python-modules/amqtt { };
 
   amshan = callPackage ../development/python-modules/amshan { };