diff --git a/pkgs/development/python-modules/anywidget/default.nix b/pkgs/development/python-modules/anywidget/default.nix
index e79ac1a6e939..1420201e9707 100644
--- a/pkgs/development/python-modules/anywidget/default.nix
+++ b/pkgs/development/python-modules/anywidget/default.nix
@@ -59,6 +59,16 @@ buildPythonPackage rec {
   disabledTests = [
     # requires package.json
     "test_version"
+
+    # AssertionError: assert not {140737277121872: <MockComm id='140737277118512'>}
+    "test_descriptor_with_psygnal"
+    "test_descriptor_with_pydantic"
+    "test_descriptor_with_msgspec"
+    "test_descriptor_with_traitlets"
+    "test_infer_file_contents"
+
+    #  assert not {<function _connect_psygnal.<locals>._disconnect at 0x7ffff3617e...
+    "test_descriptor_with_psygnal"
   ];
 
   pythonImportsCheck = [ "anywidget" ];