diff --git a/pkgs/development/python-modules/cocotb/default.nix b/pkgs/development/python-modules/cocotb/default.nix
index f69e6f81827c..5b25f03143ca 100644
--- a/pkgs/development/python-modules/cocotb/default.nix
+++ b/pkgs/development/python-modules/cocotb/default.nix
@@ -4,6 +4,7 @@
   fetchFromGitHub,
   setuptools,
   setuptools-scm,
+  python,
   cocotb-bus,
   find-libpython,
   pytestCheckHook,
@@ -46,6 +47,14 @@ buildPythonPackage rec {
     substituteInPlace setup.py --replace "'cocotb-bus<1.0'" ""
   '';
 
+  # cocotb uses dlopen so that it's dynamic libraries are python version agnostic.
+  # Here we patch its dynamic libraries to make sure the correct libpython is found and used.
+  preFixup = lib.optionalString stdenv.hostPlatform.isLinux ''
+    for lib in $out/lib/python*/site-packages/cocotb/libs/*.so; do
+      patchelf --add-rpath ${python}/lib --add-needed libpython3.so $lib
+    done
+  '';
+
   disabledTests = [
     # https://github.com/cocotb/cocotb/commit/425e1edb8e7133f4a891f2f87552aa2748cd8d2c#diff-4df986cbc2b1a3f22172caea94f959d8fcb4a128105979e6e99c68139469960cL33
     "test_cocotb"