diff --git a/pkgs/development/python-modules/pyquil/default.nix b/pkgs/development/python-modules/pyquil/default.nix
index 00351c5dc516..72ba19f8a2e8 100644
--- a/pkgs/development/python-modules/pyquil/default.nix
+++ b/pkgs/development/python-modules/pyquil/default.nix
@@ -12,7 +12,9 @@
 , pytest-httpx
 , pytest-mock
 , pytestCheckHook
+, pythonAtLeast
 , pythonOlder
+, pythonRelaxDepsHook
 , qcs-api-client
 , respx
 , retry
@@ -24,7 +26,7 @@
 
 buildPythonPackage rec {
   pname = "pyquil";
-  version = "3.3.2";
+  version = "3.3.3";
   format = "pyproject";
 
   disabled = pythonOlder "3.7";
@@ -32,12 +34,17 @@ buildPythonPackage rec {
   src = fetchFromGitHub {
     owner = "rigetti";
     repo = pname;
-    rev = "v${version}";
-    hash = "sha256-Ur7dRxmnaAWXHk7c6NC3lBw59RRgh9vwAHFW00fViD4=";
+    rev = "refs/tags/v${version}";
+    hash = "sha256-jA6nYQSfdxd9FCTMQlYTe/EbV39vV0h9F9Fgf1M0+SY=";
   };
 
+  pythonRelaxDeps = [
+    "lark"
+  ];
+
   nativeBuildInputs = [
     poetry-core
+    pythonRelaxDepsHook
   ];
 
   propagatedBuildInputs = [
@@ -55,21 +62,18 @@ buildPythonPackage rec {
   ];
 
   nativeCheckInputs = [
+    pytestCheckHook
+  ];
+
+  checkInputs = [
     pytest-asyncio
     pytest-freezegun
     pytest-httpx
     pytest-mock
-    pytestCheckHook
     respx
     ipython
   ];
 
-  postPatch = ''
-    substituteInPlace pyproject.toml \
-      --replace 'lark = "^0.11.1"' 'lark = "*"' \
-      --replace 'qcs-api-client = ">=0.8.1,<0.21.0"' 'qcs-api-client = "*"'
-  '';
-
   disabledTestPaths = [
     # Tests require network access
     "test/e2e/"
@@ -85,6 +89,8 @@ buildPythonPackage rec {
     "test/unit/test_reference_wavefunction.py"
     # Out-dated
     "test/unit/test_qpu_client.py"
+    "test/unit/test_qvm_client.py"
+    "test/unit/test_reference_density.py"
   ];
 
   disabledTests = [
@@ -102,6 +108,7 @@ buildPythonPackage rec {
   meta = with lib; {
     description = "Python library for creating Quantum Instruction Language (Quil) programs";
     homepage = "https://github.com/rigetti/pyquil";
+    changelog = "https://github.com/rigetti/pyquil/blob/v${version}/CHANGELOG.md";
     license = licenses.asl20;
     maintainers = with maintainers; [ fab ];
   };
diff --git a/pkgs/development/python-modules/qcs-api-client/default.nix b/pkgs/development/python-modules/qcs-api-client/default.nix
index 74b688c232f4..48b0e0ac7e04 100644
--- a/pkgs/development/python-modules/qcs-api-client/default.nix
+++ b/pkgs/development/python-modules/qcs-api-client/default.nix
@@ -11,7 +11,9 @@
 , pytest-asyncio
 , pytestCheckHook
 , python-dateutil
+, pythonAtLeast
 , pythonOlder
+, pythonRelaxDepsHook
 , respx
 , retrying
 , rfc3339
@@ -20,7 +22,7 @@
 
 buildPythonPackage rec {
   pname = "qcs-api-client";
-  version = "0.21.2";
+  version = "0.21.3";
   format = "pyproject";
 
   disabled = pythonOlder "3.7";
@@ -29,11 +31,26 @@ buildPythonPackage rec {
     owner = "rigetti";
     repo = "qcs-api-client-python";
     rev = "refs/tags/v${version}";
-    hash = "sha256-gQow1bNRPhUm4zRu2T5FpcgOTcS2F1TQIz8WP1K0Xww=";
+    hash = "sha256-GEsCyqawLX6fTICjAOOREsO5FsmV6U/5+sDOW1v+VKE=";
   };
 
+  patches = [
+    # Switch to poetry-core, https://github.com/rigetti/qcs-api-client-python/pull/2
+    (fetchpatch {
+      name = "switch-to-poetry-core.patch";
+      url = "https://github.com/rigetti/qcs-api-client-python/commit/32f0b3c7070a65f4edf5b2552648d88435469e44.patch";
+      hash = "sha256-mOc+Q/5cmwPziojtxeEMWWHSDvqvzZlNRbPtOSeTinQ=";
+    })
+  ];
+
+  pythonRelaxDeps = [
+    "attrs"
+    "httpx"
+  ];
+
   nativeBuildInputs = [
     poetry-core
+    pythonRelaxDepsHook
   ];
 
   propagatedBuildInputs = [
@@ -54,32 +71,8 @@ buildPythonPackage rec {
     respx
   ];
 
-  patches = [
-    # Switch to poetry-core, https://github.com/rigetti/qcs-api-client-python/pull/2
-    (fetchpatch {
-      name = "switch-to-poetry-core.patch";
-      url = "https://github.com/rigetti/qcs-api-client-python/commit/32f0b3c7070a65f4edf5b2552648d88435469e44.patch";
-      hash = "sha256-mOc+Q/5cmwPziojtxeEMWWHSDvqvzZlNRbPtOSeTinQ=";
-    })
-  ];
-
-  postPatch = ''
-    substituteInPlace pyproject.toml \
-      --replace 'attrs = "^20.1.0"' 'attrs = "*"' \
-      --replace 'httpx = "^0.15.0"' 'httpx = "*"' \
-      --replace 'iso8601 = "^0.1.13"' 'iso8601 = "*"' \
-      --replace 'pydantic = "^1.7.2"' 'pydantic = "*"' \
-      --replace 'pyjwt = "^1.7.1"' 'pyjwt = "*"'
-  '';
-
-  disabledTestPaths = [
-    # Test is outdated
-    "tests/test_client/test_additional_properties.py"
-    "tests/test_client/test_auth.py"
-    "tests/test_client/test_client.py"
-    "tests/test_client/test_datetime.py"
-    "tests/test_imports.py"
-  ];
+  # Tests are failing on Python 3.11, Fatal Python error: Aborted
+  doCheck = !(pythonAtLeast "3.11");
 
   pythonImportsCheck = [
     "qcs_api_client"
@@ -88,6 +81,7 @@ buildPythonPackage rec {
   meta = with lib; {
     description = "Python library for accessing the Rigetti QCS API";
     homepage = "https://qcs-api-client-python.readthedocs.io/";
+    changelog = "https://github.com/rigetti/qcs-api-client-python/releases/tag/v${version}";
     license = licenses.asl20;
     maintainers = with maintainers; [ fab ];
   };