diff --git a/pkgs/tools/misc/diffoscope/default.nix b/pkgs/tools/misc/diffoscope/default.nix
index 82c6bbebe774..5c30b40f22ee 100644
--- a/pkgs/tools/misc/diffoscope/default.nix
+++ b/pkgs/tools/misc/diffoscope/default.nix
@@ -3,23 +3,31 @@
 , e2fsprogs, file, findutils, fontforge-fonttools, ffmpeg, fpc, gettext, ghc, ghostscriptX, giflib, gnumeric, gnupg, gnutar
 , gzip, hdf5, imagemagick, jdk, libarchive, libcaca, llvm, lz4, mono, openssh, openssl, pdftk, pgpdump, poppler_utils, qemu, R
 , radare2, sng, sqlite, squashfsTools, tcpdump, odt2txt, unzip, wabt, xxd, xz, zip, zstd
+, fetchpatch
 , enableBloat ? false
 }:
 
 # Note: when upgrading this package, please run the list-missing-tools.sh script as described below!
 python3Packages.buildPythonApplication rec {
   pname = "diffoscope";
-  version = "180";
+  version = "181";
 
   src = fetchurl {
     url = "https://diffoscope.org/archive/diffoscope-${version}.tar.bz2";
-    sha256 = "sha256-P6u+5MwnJ4xQ955qdX1I/ujRCcgyCXjXDXvvpUbhqt8=";
+    sha256 = "sha256-wom3/r0oR7K8zdz1GxLImQ4Whc4WpzPGwjqXb39mxw4=";
   };
 
   outputs = [ "out" "man" ];
 
   patches = [
     ./ignore_links.patch
+
+    # Fixes a minor issue with squashfs >=4.5 (which we already have). Already
+    # in upstream's master, can be removed when updating to 182.
+    (fetchpatch {
+      url = "https://salsa.debian.org/reproducible-builds/diffoscope/-/commit/9e410d6fd4def177c4b5f914e74f72a59fb1a316.patch";
+      sha256 = "sha256-Nj5Up48lfekH8KCPaucDb78QbtJ91O2SNiA4SqBrCBI=";
+    })
   ];
 
   postPatch = ''