diff --git a/pkgs/build-support/cc-wrapper/default.nix b/pkgs/build-support/cc-wrapper/default.nix
index 50ff90609a5e..427161f4742c 100644
--- a/pkgs/build-support/cc-wrapper/default.nix
+++ b/pkgs/build-support/cc-wrapper/default.nix
@@ -741,14 +741,14 @@ stdenvNoCC.mkDerivation {
     # https://github.com/NixOS/nixpkgs/pull/209870#issuecomment-1500550903)
     + optionalString (libcxx == null && isClang && (useGccForLibs && gccForLibs.langCC or false)) ''
       for dir in ${gccForLibs}/include/c++/*; do
-        include -isystem "$dir" >> $out/nix-support/libcxx-cxxflags
+        include -cxx-isystem "$dir" >> $out/nix-support/libcxx-cxxflags
       done
       for dir in ${gccForLibs}/include/c++/*/${targetPlatform.config}; do
-        include -isystem "$dir" >> $out/nix-support/libcxx-cxxflags
+        include -cxx-isystem "$dir" >> $out/nix-support/libcxx-cxxflags
       done
     ''
     + optionalString (libcxx.isLLVM or false) ''
-      include -isystem "${getDev libcxx}/include/c++/v1" >> $out/nix-support/libcxx-cxxflags
+      include -cxx-isystem "${getDev libcxx}/include/c++/v1" >> $out/nix-support/libcxx-cxxflags
       echo "-stdlib=libc++" >> $out/nix-support/libcxx-ldflags
     ''
     # GCC NG friendly libc++