diff --git a/pkgs/by-name/aw/awscli2/package.nix b/pkgs/by-name/aw/awscli2/package.nix
index 451bb46c7de1..ebdc30b799a8 100644
--- a/pkgs/by-name/aw/awscli2/package.nix
+++ b/pkgs/by-name/aw/awscli2/package.nix
@@ -119,6 +119,14 @@ py.pkgs.buildPythonApplication rec {
     less
   ];
 
+  # Prevent breakage when running in a Python environment: https://github.com/NixOS/nixpkgs/issues/47900
+  makeWrapperArgs = [
+    "--unset"
+    "NIX_PYTHONPATH"
+    "--unset"
+    "PYTHONPATH"
+  ];
+
   nativeCheckInputs = with py.pkgs; [
     addBinToPathHook
     jsonschema