diff --git a/pkgs/development/python-modules/itkwasm-downsample/default.nix b/pkgs/development/python-modules/itkwasm-downsample/default.nix
new file mode 100644
index 000000000000..6e0176183017
--- /dev/null
+++ b/pkgs/development/python-modules/itkwasm-downsample/default.nix
@@ -0,0 +1,48 @@
+{
+  lib,
+  buildPythonPackage,
+  fetchPypi,
+  hatch-vcs,
+  hatchling,
+  itkwasm,
+  itkwasm-downsample-emscripten,
+  itkwasm-downsample-wasi,
+  writableTmpDirAsHomeHook,
+}:
+
+buildPythonPackage (finalAttrs: {
+  pname = "itkwasm-downsample";
+  version = "1.8.1";
+  pyproject = true;
+
+  src = fetchPypi {
+    pname = "itkwasm_downsample";
+    inherit (finalAttrs) version;
+    hash = "sha256-tKkct5+39p5jM/vBj3RTSM1YZZoLnajh85Eon4/wavs=";
+  };
+
+  build-system = [
+    hatch-vcs
+    hatchling
+  ];
+
+  nativeBuildInputs = [ writableTmpDirAsHomeHook ];
+
+  dependencies = [
+    itkwasm
+    itkwasm-downsample-emscripten
+    itkwasm-downsample-wasi
+  ];
+
+  # No tests available
+  doCheck = false;
+
+  pythonImportsCheck = [ "itkwasm_downsample" ];
+
+  meta = {
+    description = "Pipelines for downsampling images";
+    homepage = "https://pypi.org/project/itkwasm-downsample";
+    license = lib.licenses.asl20;
+    maintainers = with lib.maintainers; [ fab ];
+  };
+})