diff --git a/pkgs/tools/virtualization/euca2ools/default.nix b/pkgs/tools/virtualization/euca2ools/default.nix
deleted file mode 100644
index 88e83f42733e..000000000000
--- a/pkgs/tools/virtualization/euca2ools/default.nix
+++ /dev/null
@@ -1,23 +0,0 @@
-{ lib, fetchgit, python2Packages }:
-
-let
-  inherit (python2Packages) buildPythonApplication boto m2crypto;
-in buildPythonApplication {
-  pname = "euca2ools";
-  version = "2.1.4";
-
-  src = fetchgit {
-    url = "https://github.com/eucalyptus/euca2ools.git";
-    rev = "19cb7eac34dd7efe3a56e4841b9692c03458bf3b";
-    sha256 = "0grsgn5gbvk1hlfa8qx7ppz7iyfyi2pdhxy8njr8lm60w4amfiyq";
-  };
-
-  propagatedBuildInputs = [ boto m2crypto ];
-
-  meta = {
-    homepage = "https://github.com/eucalyptus/euca2ools";
-    description = "Tools for interacting with Amazon EC2/S3-compatible cloud computing services";
-    maintainers = [ lib.maintainers.eelco ];
-    platforms = lib.platforms.linux;
-  };
-}
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index 5d38d318972e..cc08d49341fc 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -233,6 +233,7 @@ mapAliases ({
   envelope = throw "envelope has been removed from nixpkgs, as it was unmaintained."; # added 2021-08-05
   epoxy = libepoxy; # 2021-11-11
   esniper = throw "esniper has been removed because upstream no longer maintains it (and it no longer works)"; # added 2021-04-12
+  euca2tools = throw "euca2ools has been removed because it is unmaintained upstream and still uses python2."; # added 2022-01-01
   evolution_data_server = evolution-data-server; # added 2018-02-25
   etcdctl = etcd; # added 2018-04-25
   exfat-utils = exfat;                  # 2015-09-11
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 5305c75a8822..4b6dadf075de 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -5131,8 +5131,6 @@ with pkgs;
 
   ettercap = callPackage ../applications/networking/sniffers/ettercap { };
 
-  euca2ools = callPackage ../tools/virtualization/euca2ools { };
-
   eventstat = callPackage ../os-specific/linux/eventstat { };
 
   evillimiter = python3Packages.callPackage ../tools/networking/evillimiter { };