diff --git a/pkgs/by-name/hy/hyx/package.nix b/pkgs/by-name/hy/hyx/package.nix
index e41f9bbfceb2..a33f619af291 100644
--- a/pkgs/by-name/hy/hyx/package.nix
+++ b/pkgs/by-name/hy/hyx/package.nix
@@ -1,4 +1,4 @@
-{ lib, stdenv, fetchurl, memstreamHook }:
+{ lib, stdenv, fetchurl }:
 
 stdenv.mkDerivation rec {
   pname = "hyx";
@@ -14,8 +14,6 @@ stdenv.mkDerivation rec {
       --replace "-Wl,-z,relro,-z,now -fpic -pie" ""
   '';
 
-  buildInputs = lib.optional (stdenv.system == "x86_64-darwin") memstreamHook;
-
   installPhase = ''
     install -vD hyx $out/bin/hyx
   '';
diff --git a/pkgs/by-name/no/notemap/package.nix b/pkgs/by-name/no/notemap/package.nix
index 0611665d6618..040f26752b51 100644
--- a/pkgs/by-name/no/notemap/package.nix
+++ b/pkgs/by-name/no/notemap/package.nix
@@ -3,7 +3,6 @@
 , fetchzip
 , pkg-config
 , libressl
-, memstreamHook
 }:
 
 stdenv.mkDerivation rec {
@@ -21,8 +20,6 @@ stdenv.mkDerivation rec {
 
   buildInputs = [
     libressl
-  ] ++ lib.optionals (stdenv.hostPlatform.isDarwin && stdenv.hostPlatform.isx86_64) [
-    memstreamHook
   ];
 
   meta = {
diff --git a/pkgs/by-name/te/telescope/package.nix b/pkgs/by-name/te/telescope/package.nix
index 801cae0b123c..7f1f23d07ad4 100644
--- a/pkgs/by-name/te/telescope/package.nix
+++ b/pkgs/by-name/te/telescope/package.nix
@@ -9,7 +9,6 @@
 , ncurses
 , autoreconfHook
 , buildPackages
-, memstreamHook
 }:
 
 stdenv.mkDerivation rec {
@@ -39,7 +38,7 @@ stdenv.mkDerivation rec {
     libgrapheme
     libressl
     ncurses
-  ] ++ lib.optional stdenv.hostPlatform.isDarwin memstreamHook;
+  ];
 
   configureFlags = [
     "HOSTCC=${buildPackages.stdenv.cc}/bin/${buildPackages.stdenv.cc.targetPrefix}cc"
diff --git a/pkgs/by-name/ti/tintin/package.nix b/pkgs/by-name/ti/tintin/package.nix
index 6f56512b1da2..a5959098d8aa 100644
--- a/pkgs/by-name/ti/tintin/package.nix
+++ b/pkgs/by-name/ti/tintin/package.nix
@@ -1,5 +1,5 @@
 { stdenv, fetchFromGitHub, lib, zlib, pcre
-, memorymappingHook, memstreamHook
+, memorymappingHook
 , gnutls
 }:
 
@@ -15,7 +15,7 @@ stdenv.mkDerivation rec {
   };
 
   buildInputs = [ zlib pcre gnutls ]
-    ++ lib.optionals (stdenv.system == "x86_64-darwin") [ memorymappingHook memstreamHook ];
+    ++ lib.optionals (stdenv.system == "x86_64-darwin") [ memorymappingHook ];
 
   preConfigure = ''
     cd src
diff --git a/pkgs/by-name/ut/util-linux/package.nix b/pkgs/by-name/ut/util-linux/package.nix
index 6afae4dcc963..1e6569a44dc6 100644
--- a/pkgs/by-name/ut/util-linux/package.nix
+++ b/pkgs/by-name/ut/util-linux/package.nix
@@ -14,7 +14,6 @@
 , installShellFiles
 , writeSupport ? stdenv.hostPlatform.isLinux
 , shadowSupport ? stdenv.hostPlatform.isLinux
-, memstreamHook
 , gitUpdater
 }:
 
@@ -90,8 +89,7 @@ stdenv.mkDerivation rec {
     ++ lib.optionals pamSupport [ pam ]
     ++ lib.optionals capabilitiesSupport [ libcap_ng ]
     ++ lib.optionals ncursesSupport [ ncurses ]
-    ++ lib.optionals systemdSupport [ systemd ]
-    ++ lib.optionals (stdenv.system == "x86_64-darwin") [ memstreamHook ];
+    ++ lib.optionals systemdSupport [ systemd ];
 
   doCheck = false; # "For development purpose only. Don't execute on production system!"
 
diff --git a/pkgs/by-name/xf/xfitter/package.nix b/pkgs/by-name/xf/xfitter/package.nix
index e509f3a005f7..d6d1705054b8 100644
--- a/pkgs/by-name/xf/xfitter/package.nix
+++ b/pkgs/by-name/xf/xfitter/package.nix
@@ -18,7 +18,7 @@
 , qcdnum
 , root
 , zlib
-, memorymappingHook, memstreamHook
+, memorymappingHook
 }:
 
 stdenv.mkDerivation rec {
@@ -40,7 +40,7 @@ stdenv.mkDerivation rec {
   buildInputs =
     [ apfel blas ceres-solver lhapdf lapack libyaml root qcdnum gsl yaml-cpp zlib ]
     ++ lib.optionals ("5" == lib.versions.major root.version) [ apfelgrid applgrid ]
-    ++ lib.optionals (stdenv.system == "x86_64-darwin") [ memorymappingHook memstreamHook ]
+    ++ lib.optionals (stdenv.system == "x86_64-darwin") [ memorymappingHook ]
     ++ lib.optional (stdenv.hostPlatform.libc == "glibc") libtirpc
     ;
 
diff --git a/pkgs/development/libraries/memstream/default.nix b/pkgs/development/libraries/memstream/default.nix
deleted file mode 100644
index 7877718e6d35..000000000000
--- a/pkgs/development/libraries/memstream/default.nix
+++ /dev/null
@@ -1,48 +0,0 @@
-{ lib, stdenv, fetchurl }:
-
-stdenv.mkDerivation rec {
-  pname = "memstream";
-  version = "0.1";
-
-  src = fetchurl {
-    url = "https://piumarta.com/software/memstream/memstream-${version}.tar.gz";
-    sha256 = "0kvdb897g7nyviaz72arbqijk2g2wa61cmi3l5yh48rzr49r3a3a";
-  };
-
-  postPatch = ''
-    substituteInPlace Makefile \
-      --replace-fail 'cc' '$(CC)'
-  '';
-
-  dontConfigure = true;
-
-  postBuild = ''
-    $AR rcs libmemstream.a memstream.o
-  '';
-
-  doCheck = stdenv.buildPlatform.canExecute stdenv.hostPlatform;
-  checkPhase = ''
-    runHook preCheck
-
-    ./test | grep "This is a test of memstream"
-
-    runHook postCheck
-  '';
-
-  installPhase = ''
-    runHook preInstall
-
-    install -D libmemstream.a "$out"/lib/libmemstream.a
-    install -D memstream.h "$out"/include/memstream.h
-
-    runHook postInstall
-  '';
-
-  meta = with lib; {
-    homepage = "https://www.piumarta.com/software/memstream/";
-    description = "memstream.c is an implementation of the POSIX function open_memstream() for BSD and BSD-like operating systems";
-    license = licenses.mit;
-    maintainers = with maintainers; [ veprbl ];
-    platforms = platforms.unix;
-  };
-}
diff --git a/pkgs/development/libraries/memstream/setup-hook.sh b/pkgs/development/libraries/memstream/setup-hook.sh
deleted file mode 100644
index 09aabe748841..000000000000
--- a/pkgs/development/libraries/memstream/setup-hook.sh
+++ /dev/null
@@ -1,6 +0,0 @@
-useMemstream () {
-  export NIX_CFLAGS_COMPILE="${NIX_CFLAGS_COMPILE-}${NIX_CFLAGS_COMPILE:+ }-include memstream.h";
-  export NIX_LDFLAGS="${NIX_LDFLAGS-}${NIX_LDFLAGS:+ }-lmemstream";
-}
-
-postHooks+=(useMemstream)
diff --git a/pkgs/development/python-modules/pymupdf/default.nix b/pkgs/development/python-modules/pymupdf/default.nix
index 0b30312c480e..1271cd8a0b21 100644
--- a/pkgs/development/python-modules/pymupdf/default.nix
+++ b/pkgs/development/python-modules/pymupdf/default.nix
@@ -19,7 +19,6 @@
   jbig2dec,
   libjpeg_turbo,
   gumbo,
-  memstreamHook,
 
   # dependencies
   mupdf,
@@ -75,7 +74,7 @@ buildPythonPackage rec {
     jbig2dec
     libjpeg_turbo
     gumbo
-  ] ++ lib.optionals (stdenv.system == "x86_64-darwin") [ memstreamHook ];
+  ];
 
   propagatedBuildInputs = [ mupdf-cxx ];
 
diff --git a/pkgs/tools/misc/timidity/default.nix b/pkgs/tools/misc/timidity/default.nix
index f41d3b34971a..1ad1a0682b81 100644
--- a/pkgs/tools/misc/timidity/default.nix
+++ b/pkgs/tools/misc/timidity/default.nix
@@ -3,7 +3,6 @@
 , fetchurl
 , nixosTests
 , pkg-config
-, memstreamHook
 , CoreAudio
 , libobjc
 , libjack2
@@ -31,9 +30,7 @@ stdenv.mkDerivation rec {
     ./configure-compat.patch
   ];
 
-  nativeBuildInputs = [ pkg-config ]
-    ++ lib.optionals (stdenv.hostPlatform.isDarwin && stdenv.hostPlatform.isx86_64) [ memstreamHook ];
-
+  nativeBuildInputs = [ pkg-config ];
   buildInputs = [
     libjack2
     ncurses
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index d28db7363fe1..eedc995e5431 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -765,6 +765,8 @@ mapAliases {
   mcomix3 = mcomix; # Added 2022-06-05
   mdt = md-tui; # Added 2024-09-03
   meme = throw "'meme' has been renamed to/replaced by 'meme-image-generator'"; # Converted to throw 2024-10-17
+  memstream = throw "memstream has been removed, as it was only useful on old macOS versions that are no longer supported"; # Added 2024-10-05
+  memstreamHook = throw "memstream has been removed, as it was only useful on old macOS versions that are no longer supported"; # Added 2024-10-05
   mhwaveedit = throw "'mkwaveedit' has been removed due to lack of maintenance upstream. Consider using 'audacity' or 'tenacity' instead";
   microcodeAmd = microcode-amd; # Added 2024-09-08
   microcodeIntel = microcode-intel; # Added 2024-09-08
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 6018ed75c44d..08afcabfe14d 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -10360,12 +10360,6 @@ with pkgs;
     propagatedBuildInputs = [ memorymapping ];
   } ../development/libraries/memorymapping/setup-hook.sh;
 
-  memstream = callPackage ../development/libraries/memstream { };
-  memstreamHook = makeSetupHook {
-    name = "memstream-hook";
-    propagatedBuildInputs = [ memstream ];
-  } ../development/libraries/memstream/setup-hook.sh;
-
   mergerfs = callPackage ../tools/filesystems/mergerfs { };
 
   mergerfs-tools = callPackage ../tools/filesystems/mergerfs/tools.nix { };