diff --git a/pkgs/development/libraries/ffmpeg/generic.nix b/pkgs/development/libraries/ffmpeg/generic.nix
index 271057d7cfa0..bc51ce177bc5 100644
--- a/pkgs/development/libraries/ffmpeg/generic.nix
+++ b/pkgs/development/libraries/ffmpeg/generic.nix
@@ -79,6 +79,7 @@
       && !isAarch32
       && !hostPlatform.isLoongArch64
       && !hostPlatform.isRiscV
+      && !(hostPlatform.isPower && hostPlatform.isBigEndian)
       && hostPlatform == buildPlatform
     ), # dynamically linked Nvidia code
   withFlite ? withFullDeps, # Voice Synthesis