diff --git a/pkgs/by-name/cl/clamav/package.nix b/pkgs/by-name/cl/clamav/package.nix
index 50d7e8d87a60..e1c0fb47a873 100644
--- a/pkgs/by-name/cl/clamav/package.nix
+++ b/pkgs/by-name/cl/clamav/package.nix
@@ -34,9 +34,8 @@ stdenv.mkDerivation rec {
   };
 
   patches = [
-    # Flaky test, remove this when https://github.com/Cisco-Talos/clamav/issues/343 is fixed
-    ./remove-freshclam-test.patch
-    ./sample-cofiguration-file-install-location.patch
+    ./sample-configuration-file-install-location.patch
+    ./use-non-existent-file-with-proper-permissions.patch
   ];
 
   enableParallelBuilding = true;
@@ -69,7 +68,9 @@ stdenv.mkDerivation rec {
     "-DAPP_CONFIG_DIRECTORY=/etc/clamav"
   ];
 
-  doCheck = true;
+  # Seems to only fail on x86_64-darwin with sandboxing
+  doCheck = !(stdenv.hostPlatform.isDarwin && stdenv.hostPlatform.isx86_64);
+  __darwinAllowLocalNetworking = true;
 
   checkInputs = [
     python3.pkgs.pytest
diff --git a/pkgs/by-name/cl/clamav/remove-freshclam-test.patch b/pkgs/by-name/cl/clamav/remove-freshclam-test.patch
deleted file mode 100644
index 93078b52aaad..000000000000
--- a/pkgs/by-name/cl/clamav/remove-freshclam-test.patch
+++ /dev/null
@@ -1,20 +0,0 @@
-diff --git a/unit_tests/CMakeLists.txt b/unit_tests/CMakeLists.txt
-index 1460357ba..1194abc9d 100644
---- a/unit_tests/CMakeLists.txt
-+++ b/unit_tests/CMakeLists.txt
-@@ -371,15 +371,6 @@ if(ENABLE_APP)
-         set_property(TEST clamd_valgrind PROPERTY ENVIRONMENT ${ENVIRONMENT} VALGRIND=${Valgrind_EXECUTABLE})
-     endif()
- 
--    add_test(NAME freshclam COMMAND ${PythonTest_COMMAND};freshclam_test.py
--        WORKING_DIRECTORY ${CMAKE_CURRENT_SOURCE_DIR})
--    set_property(TEST freshclam PROPERTY ENVIRONMENT ${ENVIRONMENT})
--    if(Valgrind_FOUND)
--        add_test(NAME freshclam_valgrind COMMAND ${PythonTest_COMMAND};freshclam_test.py
--            WORKING_DIRECTORY ${CMAKE_CURRENT_SOURCE_DIR})
--        set_property(TEST freshclam_valgrind PROPERTY ENVIRONMENT ${ENVIRONMENT} VALGRIND=${Valgrind_EXECUTABLE})
--    endif()
--
-     add_test(NAME sigtool COMMAND ${PythonTest_COMMAND};sigtool_test.py
-         WORKING_DIRECTORY ${CMAKE_CURRENT_SOURCE_DIR})
-     set_property(TEST sigtool PROPERTY ENVIRONMENT ${ENVIRONMENT})
diff --git a/pkgs/by-name/cl/clamav/sample-cofiguration-file-install-location.patch b/pkgs/by-name/cl/clamav/sample-configuration-file-install-location.patch
similarity index 100%
rename from pkgs/by-name/cl/clamav/sample-cofiguration-file-install-location.patch
rename to pkgs/by-name/cl/clamav/sample-configuration-file-install-location.patch
diff --git a/pkgs/by-name/cl/clamav/use-non-existent-file-with-proper-permissions.patch b/pkgs/by-name/cl/clamav/use-non-existent-file-with-proper-permissions.patch
new file mode 100644
index 000000000000..0cbc3cb6583d
--- /dev/null
+++ b/pkgs/by-name/cl/clamav/use-non-existent-file-with-proper-permissions.patch
@@ -0,0 +1,13 @@
+diff --git a/unit_tests/check_clamd.c b/unit_tests/check_clamd.c
+index 2f526709a..df67c36ed 100644
+--- a/unit_tests/check_clamd.c
++++ b/unit_tests/check_clamd.c
+@@ -144,7 +144,7 @@ static void conn_teardown(void)
+ #define CLEANREPLY CLEANFILE ": OK"
+ #define UNKNOWN_REPLY "UNKNOWN COMMAND"
+ 
+-#define NONEXISTENT PATHSEP "nonexistentfilename"
++#define NONEXISTENT PATHSEP "tmp" PATHSEP "nonexistentfilename"
+ 
+ #define NONEXISTENT_REPLY NONEXISTENT ": File path check failure: No such file or directory. ERROR"
+